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Showing 1–10 of 10 results
Advanced filters: Author: Sanjeev S. Ranade Clear advanced filters

  • Studies using human pluripotent stem cells and a mouse model of Down syndrome identify HMGN1 as a key contributor to congenital heart defects in individuals with Down syndrome.

    • Sanjeev S. Ranade
    • Feiya Li
    • Deepak Srivastava
    ResearchOpen Access
    Nature
    Volume: 647, P: 979-987

  • By performing a genome-wide CRISPR screen in human induced pluripotent stem cells, Padmanabhan et al. identify the acetyl-lysine reader protein BRD4 as a regulator of cardiomyocyte differentiation, and they validate in vivo that BRD4 is required during development for the fate determination of a subset of secondary heart field cardiac progenitor cells.

    • Arun Padmanabhan
    • T. Yvanka de Soysa
    • Rajan Jain
    Research
    Nature Cardiovascular Research
    Volume: 3, P: 317-331

  • Auditory hair cells contain mechanotransduction channels that are activated by sound. The authors show that Piezo2, a mechanotransduction channel important for touch perception, is expressed in auditory hair cells. Surprisingly, Piezo2 is not the mechanotransduction channel essential for auditory perception and is instead observed after damage to hair cells.

    • Zizhen Wu
    • Nicolas Grillet
    • Ulrich Müller
    Research
    Nature Neuroscience
    Volume: 20, P: 24-33

  • The cellular basis of touch has long been debated, in particular the relationship between sensory neurons and non-neuronal cells; a mouse study uses optogenetics to identify their distinct and collaborative roles, with skin-derived Merkel cells both transducing touch and actively tuning responses of touch-sensitive neurons.

    • Srdjan Maksimovic
    • Masashi Nakatani
    • Ellen A. Lumpkin
    Research
    Nature
    Volume: 509, P: 617-621

  • A mouse study shows that non-neuronal epidermal Merkel cells aid fine-touch perception in the skin through their expression of the Piezo2 mechanosensitive cation channel which then actively tunes the response to touch in adjacent somatosensory neurons.

    • Seung-Hyun Woo
    • Sanjeev Ranade
    • Ardem Patapoutian
    Research
    Nature
    Volume: 509, P: 622-626

  • Mice lacking the mechanically activated ion channel Piezo2 in both sensory neurons and Merkel cells are almost totally incapable of light-touch sensation while other somatosensory functions, such as mechanical nociception, remain intact, implying that other mechanically activated ion channels must now be identified to account for painful touch sensation.

    • Sanjeev S. Ranade
    • Seung-Hyun Woo
    • Ardem Patapoutian
    Research
    Nature
    Volume: 516, P: 121-125