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Showing 1–3 of 3 results
Advanced filters: Author: Sanne Bootsma Clear advanced filters

  • Half of all colorectal cancers bear KRAS-activating mutations that affect the metabolic dependencies of cancer cells and drive resistance to commonly used drugs. A new study provides insights into KRAS-driven metabolic rewiring and identifies a new therapeutic target for KRAS-mutant cancers.

    • Sanne Bootsma
    • Sanne M. van Neerven
    • Louis Vermeulen
    News & Views
    Nature Genetics
    Volume: 53, P: 9-10

  • Colorectal cancer can lead to the development of peritoneal metastases, which are associated with worse disease outcome. Here, the authors characterize peritoneal metastases from 52 patients using RNA-seq and mutational sequencing and show a distinct molecular subtype.

    • Kristiaan J. Lenos
    • Sander Bach
    • Louis Vermeulen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Van der Zalm et al. apply Ridge regression analysis to RNA-seq data from esophageal cancer samples to predict mesenchymal transitions occurring in patients. Expression of NANOG in pre-treatment biopsies is associated with poor response to neoadjuvant chemoradiation, recurrence, and median overall survival in patients with esophageal adenocarcinoma.

    • Amber P. van der Zalm
    • Mark P. G. Dings
    • Maarten F. Bijlsma
    ResearchOpen Access
    Communications Medicine
    Volume: 4, P: 1-11