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Showing 1–10 of 10 results
Advanced filters: Author: Santiago Vacca Clear advanced filters

  • Natural products have historically made a major contribution to pharmacotherapy, but also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization. This Review discusses recent technological developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — that are enabling a revitalization of natural product-based drug discovery.

    • Atanas G. Atanasov
    • Sergey B. Zotchev
    • Claudiu T. Supuran
    Reviews
    Nature Reviews Drug Discovery
    Volume: 20, P: 200-216

  • Here, Waltenspühl et al. report the cryo-EM structure of active human oxytocin receptor in complex with oxytocin and with a heterotrimeric G protein, providing insights into this hormone system critically involved in the regulation of social behaviour and reproduction.

    • Yann Waltenspühl
    • Janosch Ehrenmann
    • Andreas Plückthun
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

    • Céline Bellenguez
    • Fahri Küçükali
    • Jean-Charles Lambert
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 412-436

  • Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

    • Itziar de Rojas
    • Sonia Moreno-Grau
    • Agustín Ruiz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Paterson and Yu et al. demonstrate that loss of the RNA alternative splicing factor RBFOX2 in the liver during a lipogenic diet leads to dysregulation of liver lipid and cholesterol homeostasis through a specific alternative splicing programme, which includes a splice switch of the high-density lipoprotein receptor gene Scarb1.

    • Helen A. B. Paterson
    • Sijia Yu
    • Santiago Vernia
    ResearchOpen Access
    Nature Metabolism
    Volume: 4, P: 1812-1829

  • The accurate determination of quark mixing parameters is essential for the understanding of the Standard Model. The LHCb collaboration now reports the coupling strength of the b quark to the u quark through the measurement of a baryonic decay mode.

    • R. Aaij
    • B. Adeva
    • L. Zhong
    ResearchOpen Access
    Nature Physics
    Volume: 11, P: 743-747

  • CP violation has deep implications for particle physics and cosmology. Previously observed only in meson decays, signs of CP violation have now been spotted in baryon decays by analysing the proton–proton collision data from the LHCb detector.

    • R. Aaij
    • B. Adeva
    • S. Zucchelli
    ResearchOpen Access
    Nature Physics
    Volume: 13, P: 391-396

  • Combined analysis of proton-proton collision data from the Large Hadron Collider at CERN by the CMS and LHCb collaborations leads to the observation of the extremely rare decay of the strange B meson into muons; the result is compatible with the standard model of particle physics, and does not show any signs of new physics, such as supersymmetry.

    • V. Khachatryan
    • A.M. Sirunyan
    • E. Pesen
    ResearchOpen Access
    Nature
    Volume: 522, P: 68-72