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Showing 1–2 of 2 results
Advanced filters: Author: Santosh R. Rananaware Clear advanced filters

  • Cas12a is widely used in diagnostic platforms. Here the authors show that Cas12a can be programmed to directly detect RNA substrates, this is due to the 3’-end of the crRNA tolerating both RNA and DNA substrates: they use this to report a method, SAHARA, to detect RNA sequences.

    • Santosh R. Rananaware
    • Emma K. Vesco
    • Piyush K. Jain
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Nguyen et al. describe the clinical validation of the ENHANCE system, a method to detect SARS-CoV-2 based on engineered crRNAs for Cas12a and preceded by an RT-LAMP amplification step. Authors also describe the development and clinical validation of a version of this system, ENHANCEv2, that can be lyophilized and that uses another mutated Cas12a for further signal amplification.

    • Long T. Nguyen
    • Santosh R. Rananaware
    • Piyush K. Jain
    ResearchOpen Access
    Communications Medicine
    Volume: 2, P: 1-11