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Showing 1–2 of 2 results
Advanced filters: Author: Sara Merino-Aceituno Clear advanced filters

  • Epithelial-to-mesenchymal transition is a fundamental morphogenetic process that is often presented as a linear progression, though this has been challenged by in vivo observations. Here they use computational modeling to assess the impact of variability during EMT and highlight nuclear positioning and cell protrusions as drivers of cell extrusion.

    • Steffen Plunder
    • Cathy Danesin
    • Eric Theveneau
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • During mouse gastrulation the primitive streak is an area of cell division and epithelial-to-mesenchymal transition, though how mitoses and cell delamination are linked is not clear. Here they show that a faster cell cycle and relaxation of the actomyosin cytoskeleton result in the occurrence of non-apical mitosis, which favors cell delamination.

    • Evangéline Despin-Guitard
    • Viviane S. Rosa
    • Isabelle Migeotte
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18