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Advanced filters: Author: Sarah C. Erlandson Clear advanced filters

The relaxin receptor RXFP1 signals through a mechanism of autoinhibition

The RXFP1 relaxin receptor is a critical mediator of physiological adaptation to pregnancy and an emerging drug target. RXFP1 activation was found to entail an unexpected mechanism of ectodomain disinhibition resulting in downstream signaling.

Sarah C. Erlandson
Shaun Rawson
Andrew C. Kruse
Research20 Apr 2023
Nature Chemical Biology

Volume: 19, P: 1013-1021
Structural coordination of polymerization and crosslinking by a SEDS–bPBP peptidoglycan synthase complex

The crystal structure of the RodA–PBP2 complex from Thermus thermophilus elucidates how binding between these two proteins regulates their abilities to polymerize and crosslink peptidoglycan during bacterial cell wall synthesis.

Megan Sjodt
Patricia D. A. Rohs
Andrew C. Kruse
Research09 Mar 2020
Nature Microbiology

Volume: 5, P: 813-820
Yeast surface display platform for rapid discovery of conformationally selective nanobodies

Yeast surface display platform allows nanobody discovery within two to three weeks. Examples include nanobodies for crystallographic applications, targeting nonpurified antigen or conformationally selective nanobodies to two distinct human GPCRs.

Conor McMahon
Alexander S. Baier
Andrew C. Kruse
Research12 Feb 2018
Nature Structural & Molecular Biology

Volume: 25, P: 289-296