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Showing 1–9 of 9 results
Advanced filters: Author: Sarah E. Gilpin Clear advanced filters

  • Data collected from more than 2,000 taxa provide an unparalleled opportunity to quantify how extreme wildfires affect biodiversity, revealing that the largest effects on plants and animals were in areas with frequent or recent past fires and within extensively burnt areas.

    • Don A. Driscoll
    • Kristina J. Macdonald
    • Ryan D. Phillips
    ResearchOpen Access
    Nature
    Volume: 635, P: 898-905

  • Human cervical mucosa and its interactions with the microbiome play a central role in female reproductive tract health and disease. Here, the authors develop physiological models of the human cervix using Organ-on-a-Chip technology that produce mucus, and respond to hormonal, environmental, and microbial cues similar to the living cervix.

    • Zohreh Izadifar
    • Justin Cotton
    • Donald E. Ingber
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Mechanical forces in lungs facilitate breathing motions. Here the authors use a microfluidic human lung alveolus chip to study influenza infection and find that mechanical forces from active chips also induce innate inflammatory responses via, at least partially, signaling from TRPV4 and RAGE, thereby implicating them as potential therapeutic targets for lung inflammation.

    • Haiqing Bai
    • Longlong Si
    • Donald E. Ingber
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • There is a need for humanised grafts to treat patients with intestinal failure. Here, the authors generate intestinal grafts by recellularizing native intestinal matrix with human induced pluripotent stem cell-derived epithelium and human endothelium, and show nutrient absorption after transplantation in rats.

    • Kentaro Kitano
    • Dana M. Schwartz
    • Harald C. Ott
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Building on their earlier work on heart and lung organ engineering, Jeremy Song and his colleagues have now adapted the technology of using decellularized scaffolds to develop bioengineered kidneys for transplantation. When reseeded with endothelial and epithelial cells, and after orthotopic transplantation in rats, the grafts became perfused by the recipient's circulation, produced urine and provided clearance of metabolites.

    • Jeremy J Song
    • Jacques P Guyette
    • Harald C Ott
    Research
    Nature Medicine
    Volume: 19, P: 646-651

  • This describes how to decellularize whole organs using pressure-controlled perfusion, which enables preparation of acellular 3D scaffolds with preserved extracellular membrane protein content, organ architecture and perfusable vascular conduits.

    • Jacques P Guyette
    • Sarah E Gilpin
    • Harald C Ott
    Protocols
    Nature Protocols
    Volume: 9, P: 1451-1468