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Showing 1–3 of 3 results
Advanced filters: Author: Sarah Elderkin Clear advanced filters

  • Sarah Elderkin and colleagues show that PRC1 acts as a master regulator of genome architecture in mouse embryonic stem cells by organizing genes in three-dimensional interaction networks. They find that the strongest spatial network is composed of the four Hox clusters and key early developmental transcription factor genes, and they propose that selective release of genes from this spatial network underlies cell fate specification during embryonic development.

    • Stefan Schoenfelder
    • Robert Sugar
    • Sarah Elderkin
    Research
    Nature Genetics
    Volume: 47, P: 1179-1186

  • Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription. Here, the authors use single-cell RNAseq and ChIPseq to find that actively transcribed genes with Polycomb marks have greater cell-to-cell variation in expression.

    • Gozde Kar
    • Jong Kyoung Kim
    • Sarah A. Teichmann
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Protein transcription factor paralogs are not equivalent and serve distinct roles in immune cells. Merkenschlager and colleagues show that RUNX1 and RUNX3 differ in binding strength to motif sequences and how this leads to differential functional activities.

    • Ludovica Bruno
    • Vijendra Ramlall
    • Matthias Merkenschlager
    Research
    Nature Immunology
    Volume: 20, P: 1372-1380