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Showing 1–4 of 4 results
Advanced filters: Author: Sarah Hedtrich Clear advanced filters

  • Scientists worldwide struggle to identify suitable animal models to study SARS-CoV-2 infections. Interspecies-related differences, such as host specificity, divergent immune responses, or the unavailability of species-specific reagents hamper the research. Human-based models, such as micro-engineered multi-organs-on-chip, may hold the solution.

    • Partho Protim Adhikary
    • Qurrat Ul Ain
    • Sarah Hedtrich
    Comments & Opinion
    Nature Reviews Materials
    Volume: 6, P: 374-376

  • Owing to the high failure rates of the current drug development process, biomedical research is undergoing a paradigm shift towards approaches centred on human disease models. This Review critically discusses translationally relevant examples and defines key milestones for their widespread application.

    • Anna Loewa
    • James J. Feng
    • Sarah Hedtrich
    Reviews
    Nature Reviews Bioengineering
    Volume: 1, P: 545-559