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Showing 1–8 of 8 results
Advanced filters: Author: Sarah Heinicke Clear advanced filters

  • Ipecac alkaloids are plant-derived compounds historically used to induce vomiting. Here the authors elucidate how two evolutionary distant plant species have evolved to produce the same ipecac alkaloid.

    • Maite Colinas
    • Clara Morweiser
    • Sarah E. O’Connor
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 21, P: 1794-1805

  • Iridoids are terpenoid metabolites found in thousands of plants. Using single-cell transcriptomics, the authors discovered an unexpected enzyme that has been neofunctionalized to catalyse the cyclization required to form the iridoid scaffold.

    • Maite Colinas
    • Chloée Tymen
    • Sarah E. O’Connor
    ResearchOpen Access
    Nature Plants
    Volume: 11, P: 2204-2216

  • The incorporation of nitrogen in steroidal glycoalkaloids is hypothesized to occur through a transamination reaction. Here, the authors show that GLYCOALKALOID METABOLISM12 appears to evolve from the canonical γ-aminobutyric acid transaminases and directs the biosynthesis of nitrogen-containing steroidal metabolites in Solanum plants.

    • Dagny Grzech
    • Samuel J. Smit
    • Prashant D. Sonawane
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 21, P: 131-142

  • Monoterpene indole alkaloids are formed via a 3S stereoselective condensation between secologanin and tryptamine. Here the authors uncover the mechanism of epimerization behind uncommon 3R-containing alkaloids in Mitragyna speciosa (kratom) and study their inclusion in downstream biosynthesis.

    • Allwin McDonald
    • Yoko Nakamura
    • Sarah E. O’Connor
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 22, P: 229-238

  • During tomato fruit ripening, bitter and toxic steroidal glycoalkaloids (SGAs) are converted to nonbitter and less toxic forms, but proposed acylating enzyme in pathway remain unknown. Here, authors report BAHD-type acyltransferase that catalyze acylation step in biosynthesis of non-bitter SGAs in tomato.

    • Prashant D. Sonawane
    • Sachin A. Gharat
    • Asaph Aharoni
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Despite the importance of indole in plant defense and communication, its biosynthesis in core eudicots remains elusive. Here the authors report the identification of TSB-like, a pseudoenzyme that hijacks an enzyme of tryptophan biosynthesis to produce indole.

    • Matilde Florean
    • Hedwig Schultz
    • Tobias G. Köllner
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 22, P: 120-127

  • A meta-analysis of 17 cohorts of mitochondrial disease patients reveals that OxPhos defects are associated with signs of hypermetabolism. Experiments in patient-derived fibroblast show that mitochondrial OxPhos defects trigger hypermetabolism in a cell-autonomous manner and this is linked to accelerated telomere shortening and epigenetic aging.

    • Gabriel Sturm
    • Kalpita R. Karan
    • Martin Picard
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-22