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Showing 1–11 of 11 results
Advanced filters: Author: Sarah J. Hinkley Clear advanced filters

  • There has been no general increase in cancer mortality near nuclear installations in England and Wales during the period 1959-1980. Leukaemia in young people may be an exception, though the reason remains unclear.

    • David Forman
    • Paula Cook-Mozaffari
    • Malcolm Pike
    Comments & Opinion
    Nature
    Volume: 329, P: 499-505

  • Transcription activator–like effector nucleases (TALENs) are a new technology for modifying the genome at specific loci of interest. Hockemeyer et al. now demonstrate the utility of TALENs for gene targeting in human pluripotent stem cells.

    • Dirk Hockemeyer
    • Haoyi Wang
    • Rudolf Jaenisch
    Research
    Nature Biotechnology
    Volume: 29, P: 731-734

  • Tiling of regulatory DNA with mutations introduced by genome editing nucleases and linking the resulting alleles to a phenotypic readout allows the precise determination of functional sequence motifs within these regions.

    • Jeff Vierstra
    • Andreas Reik
    • John A Stamatoyannopoulos
    Research
    Nature Methods
    Volume: 12, P: 927-930

  • This study extends the natural code by which transcription activation–like effector nucleases (TALENs) recognize DNA and uses the resulting expanded repertoire of repeat divariable residues (RVDs) to improve TALEN performance.

    • Jeffrey C Miller
    • Lei Zhang
    • Edward J Rebar
    Research
    Nature Methods
    Volume: 12, P: 465-471

  • Genome editing often requires cleavage within a narrow sequence window. Here the authors develop an expanded set of zinc finger nuclease architectures that increase the available configurations by a factor of 64 and can target almost every base at loci of therapeutic significance.

    • David E. Paschon
    • Stephanie Lussier
    • Edward J. Rebar
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • TALEs (transcription activator-like effectors) are transcription factors from the plant pathogen Xanthomonas that can be readily engineered to bind new DNA sequences of interest. Miller et al. use a truncated TALE linked to a nuclease domain to edit and regulate endogenous genes in human cells.

    • Jeffrey C Miller
    • Siyuan Tan
    • Edward J Rebar
    Research
    Nature Biotechnology
    Volume: 29, P: 143-148

  • Genetic engineering in plants remains laborious and time consuming, with no precise genetic engineering methods comparable to those available in animal models. A new approach that relies on the use of designed zinc-finger nucleases is showcased here in maize, inducing herbicide tolerance that is stably inherited.

    • Vipula K. Shukla
    • Yannick Doyon
    • Fyodor D. Urnov
    Research
    Nature
    Volume: 459, P: 437-441