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Showing 1–5 of 5 results
Advanced filters: Author: Sarah K. Kummerfeld Clear advanced filters

  • Multi-omics analyses powerfully combine gene expression and translation, however no available controls can be used across these techniques. Here the authors develop pREF, a universal control construct designed for use in DNA, RNA and protein analyses.

    • Helen M. Gunter
    • Scott E. Youlten
    • Tim R. Mercer
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Transcription factors (TFs) are essential for gene expression, but very little is known about the majority of human TFs. This Analysis article provides a manually curated repertoire of sequence-specific human TFs as a foundation for future research, and examines patterns of TF expression and conservation.

    • Juan M. Vaquerizas
    • Sarah K. Kummerfeld
    • Nicholas M. Luscombe
    Research
    Nature Reviews Genetics
    Volume: 10, P: 252-263

  • ISWI chromatin remodelers regulate DNA accessibility and have been implicated in DNA damage repair. Here, the authors uncover functions, in response to DNA damage, for the bromodomain of the ISWI subunit BAZ1B and for the non-canonical PHD and bromodomain modules of the paralog BAZ1A.

    • Mariano Oppikofer
    • Meredith Sagolla
    • Andrea G. Cochran
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • Gasdermin D is identified as the required substrate for pyroptosis, mediating caspase-11 function in the non-canonical inflammasome pathway; the cleaved N-terminal domain is shown to trigger pyroptosis.

    • Nobuhiko Kayagaki
    • Irma B. Stowe
    • Vishva M. Dixit
    Research
    Nature
    Volume: 526, P: 666-671