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Showing 1–10 of 10 results
Advanced filters: Author: Sarah L. Gaffen Clear advanced filters

  • The fungus Candida albicans is ubiquitous and usually harmless in the human gut, but can also cause systemic infection. Here, Kakade et al. show that fungal secretion of an immunomodulatory toxin, candidalysin, activates a host IL-17-DUOX2 axis that regulates C. albicans colonization of the intestine.

    • Pallavi Kakade
    • Juan F. Burgueno
    • Richard J. Bennett
    ResearchOpen Access
    Nature Communications
    P: 1-15

  • Recent studies defining the structure of and signalling pathways used by receptors of the interleukin-17 family have led to interesting comparisons with the pro-inflammatory signalling pathways that are more commonly associated with innate immune receptors. Sarah Gaffen therefore suggests that T helper 17 cells might act as a bridge between innate and adaptive immunity.

    • Sarah L. Gaffen
    Reviews
    Nature Reviews Immunology
    Volume: 9, P: 556-567

  • Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for prophylactic and therapeutic intervention of mucosal candidiasis.

    • Jemima Ho
    • Xuexin Yang
    • Julian R. Naglik
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • T helper 17 (TH17) cells promote protective immune responses against infection, particularly at barrier sites, but they can also have pathogenic roles in inflammatory diseases. In this Review, the authors describe the factors that control the development and maintenance of TH17 cells, and discuss their diverse functions in both health and disease.

    • Sarah L. Gaffen
    • Renu Jain
    • Daniel J. Cua
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 585-600

  • Xiaoxia Li and colleagues discuss the roles of signaling via IL-17 and its receptor and the implications of this axis for human health, noting their normal protective roles directed against fungi and bacteria as well as against pathological conditions in inflammation and cancer.

    • Xiaoxia Li
    • Rami Bechara
    • Sarah L. Gaffen
    Reviews
    Nature Immunology
    Volume: 20, P: 1594-1602

  • This study identifies a cytolytic peptide toxin in the opportunistic human fungal pathogen Candida albicans—the peptide is both a crucial virulence factor that permeabilizes the host cell plasma membrane and a key signal that triggers a host danger response pathway.

    • David L. Moyes
    • Duncan Wilson
    • Julian R. Naglik
    Research
    Nature
    Volume: 532, P: 64-68