Understanding how genetic variation contributes to normal and pathological brain function requires integrating genetic and neuroimaging studies. New imaging consortia now make it possible to systematically assess the impact of genetic variation on the structure and function of the brain on a whole-genome and whole-brain level. In this Review, the authors summarize efforts to combine genome-wide studies with brain imaging and discuss the statistical and methodological issues necessary to insure rigor and robustness in this rapidly developing field.
- Sarah E Medland
- Neda Jahanshad
- Paul M Thompson
