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Showing 1–2 of 2 results
Advanced filters: Author: Sarah Moyon Clear advanced filters

  • Myelin formation is regulated by epigenetic mechanisms and ensures proper neuronal function during development and after demyelination. Here, the authors show that TET1, a DNA hydroxymethylase, regulates myelin repair in adult mice, but is defective with aging.

    • Sarah Moyon
    • Rebecca Frawley
    • Patrizia Casaccia
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Transient expression of the pluripotency factors Oct4, Sox2, Klf4 and c-Myc can mitigate the effects of stem cell aging on tissue health. Neumann and colleagues show that Myc expression alone converts aged oligodendrocyte progenitor cells into neonatal-like cells, and is sufficient to enhance central nervous system regeneration in an otherwise aged environment.

    • Björn Neumann
    • Michael Segel
    • Robin J. M. Franklin
    Research
    Nature Aging
    Volume: 1, P: 826-837