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Showing 1–3 of 3 results
Advanced filters: Author: Sarah Pearsall Clear advanced filters

  • Senescent cells accumulate with age and contribute to the functional decline of many tissues; however, their role in skeletal muscle is not well understood. Here the authors comprehensively assess cellular senescence in skeletal muscle of young and old mice and detail senescence features in subpopulations of p16+ fibroadipogenic progenitors and p21+ myofibers.

    • Xu Zhang
    • Leena Habiballa
    • Nathan K. LeBrasseur
    Research
    Nature Aging
    Volume: 2, P: 601-615

  • Notch signaling is known to control neuroendocrine fate in the lungs. Shue and colleagues further identify the REST and YAP transcriptional regulators as key components of the Notch signaling pathway in the control of the neuroendocrine cell fate in lung development, lung injury response, and small-cell lung cancer.

    • Yan Ting Shue
    • Alexandros P. Drainas
    • Julien Sage
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (CDX) models reveal a mechanism of drug resistance in SCLC mediated by Notch and nitric oxide activation of soluble guanylate cyclase signalling.

    • Maximilian W. Schenk
    • Sam Humphrey
    • Kristopher K. Frese
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15