Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is a rare but life-threatening severe cutaneous drug reaction mediated by CD8+ T cells. Here the authors characterise the immune response in skin samples at the site of tissue damage from patients affected with SJS/TEN and compare this to healthy skin or blister fluid and find populations of CD8+ T cell clonotypes expressing cytotoxic mediator molecules.
- Andrew Gibson
- Ramesh Ram
- Elizabeth J. Phillips
