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Nature Reviews Cancer (329)
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Showing 1–50 of 345 results

Advanced filters: Author: Sarah Seton-Rogers Clear advanced filters

Finding needles in a haystack

Sarah Seton-Rogers
Research Highlights01 Jul 2007
Nature Reviews Cancer

Volume: 7, P: 493
Finding needles in a haystack

Sarah Seton-Rogers
Research Highlights01 Jul 2007
Nature Reviews Genetics

Volume: 8, P: 491
Taking an alternative route

Sarah Seton-Rogers
Research Highlights01 Dec 2007
Nature Reviews Cancer

Volume: 7, P: 893
An alternative explanation

Sarah Seton-Rogers
Research Highlights24 Apr 2013
Nature Reviews Cancer

Volume: 13, P: 295
Modified CAR

Sarah Seton-Rogers
Research Highlights24 Apr 2013
Nature Reviews Cancer

Volume: 13, P: 295
Blocking the gatekeeper

Sarah Seton-Rogers
Research Highlights24 Nov 2014
Nature Reviews Cancer

Volume: 14, P: 766
Promoter mutations

Sarah Seton-Rogers
Research Highlights22 Feb 2013
Nature Reviews Cancer

Volume: 13, P: 149
Loss of polarity

Sarah Seton-Rogers
Research Highlights17 Oct 2013
Nature Reviews Cancer

Volume: 13, P: 757
Improving mouse models

Sarah Seton-Rogers
Research Highlights24 Apr 2013
Nature Reviews Cancer

Volume: 13, P: 295
Stop the shedding

Ferrari de Andrade et al. find that monoclonal antibodies that prevent shedding of MICA and MICB from tumour cells can restore antitumour immunity by natural killer cells.

Sarah Seton-Rogers
Research Highlights17 Apr 2018
Nature Reviews Cancer

Volume: 18, P: 338-339
Erratum: Catabolic effects

Sarah Seton-Rogers
Amendments and Corrections24 Jan 2012
Nature Reviews Cancer

Volume: 12, P: 83
SPOP mutations disrupt phase separation

Sarah Seton-Rogers
Research Highlights11 Oct 2018
Nature Reviews Cancer

Volume: 18, P: 667
Finding a rare variant

Two studies reported inNature have identified a mutation in microphthalmia-associated transcription factor (MITF) that predisposes to familial melanoma, as well as to sporadic melanoma and renal cell carcinoma.

Sarah Seton-Rogers
Research Highlights08 Dec 2011
Nature Reviews Cancer

Volume: 12, P: 1
Staying organized

A recent study published inNature Cell Biologyhas shown that tumour spheres that maintain an inverted epithelial architecture originate from primary colorectal cancers and can collectively invade the peritoneum, initiating metastasis.

Sarah Seton-Rogers
Research Highlights02 Mar 2018
Nature Reviews Cancer

Volume: 18, P: 208
Model refinement

Two papers published inNature Geneticshave reported whole-genome and whole-exome sequencing of paired Barrett oesophagus and oesophageal adenocarcinoma (EAC) samples, providing some insights into the development of EAC from its precursor lesion.

Sarah Seton-Rogers
Research Highlights13 Aug 2015
Nature Reviews Cancer

Volume: 15, P: 511
Gender-specific factors in cancer susceptibility

Sarah Seton-Rogers
Research Highlights24 May 2017
Nature Reviews Cancer

Volume: 17, P: 372
Cancer code cracked?

Complete genomes of two individual cancers sequenced.

Sarah Seton-Rogers
News01 Feb 2010
Nature Reviews Cancer

Volume: 10, P: 80
Chromatin reorganization on a 'mega' scale

Sarah Seton-Rogers
Research Highlights18 Aug 2015
Nature Reviews Genetics

Volume: 16, P: 499
Early effects of BRCA1 mutations in the breast

Bach et al. find that loss of the tumour suppressor BRCA1 may drive the development of triple negative breast cancer through inducing aberrant alveolar differentiation of luminal progenitor cells.

Sarah Seton-Rogers
Research Highlights24 Mar 2021
Nature Reviews Cancer

Volume: 21, P: 280
Metabolic mechanisms of medulloblastoma metastasis

Martirosian et al. show that a metabolic mechanism used by neurons and astrocytes during periods of nutrient deprivation and stress may have a role in leptomeningeal dissemination of medulloblastoma.

Sarah Seton-Rogers
Research Highlights19 Jul 2021
Nature Reviews Cancer

Volume: 21, P: 540
MDMX drives pre-leukaemia progression

Ueda et al. report that overexpression of MDMX in pre-leukaemic stem cells provides these cells with a competitive advantage and promotes the progression of various pre-leukaemic conditions to acute myeloid leukaemia in several mouse models.

Sarah Seton-Rogers
Research Highlights24 Mar 2021
Nature Reviews Cancer

Volume: 21, P: 280
Microbiota links to immunotherapy toxicity

Andrews et al. provide evidence that immune-related adverse events following cancer immunotherapy may be linked to the patient’s gut microbiota.

Sarah Seton-Rogers
Research Highlights19 Jul 2021
Nature Reviews Cancer

Volume: 21, P: 540
Silent mutations make noise

Kobayashi et al. describe a role for silent mutations in creating functional KRAS-Q61K and develop a strategy that could potentially target this mutant as well as other RAS-Q61X mutations.

Sarah Seton-Rogers
Research Highlights17 Mar 2022
Nature Reviews Cancer

Volume: 22, P: 257
tRNA supply and demand

Thandapani et al. examined the role for tRNA biogenesis in T cell acute lymphoblastic leukaemia (T-ALL), and found that T-ALL cells are sensitive to valine tRNA levels, which could be exploited therapeutically by dietary valine restriction.

Sarah Seton-Rogers
Research Highlights28 Jan 2022
Nature Reviews Cancer

Volume: 22, P: 129
Linking germline variants to leukaemia pathogenesis

Yang, Zhang, Luan et al. report that a germline variant that increases the risk of Philadelphia chromosome-like acute lymphoblastic leukaemia upregulates GATA3 expression, which changes chromatin accessibility to allow activation of oncogenic pathways.

Sarah Seton-Rogers
Research Highlights15 Feb 2022
Nature Reviews Cancer

Volume: 22, P: 193
STAT3 on the brain

Priego et al. show that a subpopulation of reactive astrocytes expressing signal transducer and activator of transcription 3 (STAT3) is crucial for the development of brain metastases and report positive initial clinical data that inhibiting STAT3 can reduce metastasis.

Sarah Seton-Rogers
Research Highlights09 Jul 2018
Nature Reviews Cancer

Volume: 18, P: 468-469
Subclones work together

Vinci et al. provide evidence for subclonal cooperation driving the maintenance of tumour heterogeneity in paediatric high-grade gliomas.

Sarah Seton-Rogers
Research Highlights30 Jul 2018
Nature Reviews Cancer

Volume: 18, P: 530-531
Tumours trigger systemic disruption

Breast tumours in mice promote metabolic changes in the liver and sleep disruption through increasing activity of hypocretin (also known as orexin) neurons (HO neurons).

Sarah Seton-Rogers
Research Highlights21 Jun 2018
Nature Reviews Cancer

Volume: 18, P: 468-469
mRNA alterations mimic genetic mutations

Lee, Singh et al. find that cancer-specific intronic polyadenylation events occur frequently in tumour suppressor genes in chronic lymphocytic leukaemia (CLL) and generate truncated proteins that could act as CLL drivers.

Sarah Seton-Rogers
Research Highlights21 Sept 2018
Nature Reviews Cancer

Volume: 18, P: 664-665
Altered traffic flow

Sarah Seton-Rogers
Research Highlights24 Sept 2015
Nature Reviews Cancer

Volume: 15, P: 574
Fast or slow?

An analysis of pancreatic ductal adenocarcinoma genomes indicates that many of these tumours undergo polyploidization and chromothripsis, leading to rapid acquisition of genetic changes required for tumour progression.

Sarah Seton-Rogers
Research Highlights11 Nov 2016
Nature Reviews Cancer

Volume: 16, P: 755
Two for one

Sarah Seton-Rogers
Research Highlights01 May 2009
Nature Reviews Drug Discovery

Volume: 8, P: 359
Direct hit on mutant RAS

A paper inNaturereports the design of small molecules that can irreversibly bind to and block the activity of oncogenic KRAS-G12C, but not wild-type KRAS.

Sarah Seton-Rogers
Research Highlights05 Dec 2013
Nature Reviews Cancer

Volume: 14, P: 8-9
Floxed foxes

Sarah Seton-Rogers
Research Highlights15 Feb 2007
Nature Reviews Cancer

Volume: 7, P: 161
Education is key

Two new studies have highlighted the lack of understanding many women have about their own breast cancer risk and treatment.

Sarah Seton-Rogers
News24 Sept 2013
Nature Reviews Cancer

Volume: 13, P: 680
Powerful combinations

Sarah Seton-Rogers
Research Highlights23 Nov 2016
Nature Reviews Cancer

Volume: 16, P: 757
Take it up a Notch

Sarah Seton-Rogers
Research Highlights24 Nov 2014
Nature Reviews Cancer

Volume: 14, P: 766
Nuclear functions

Sarah Seton-Rogers
Research Highlights21 Dec 2012
Nature Reviews Cancer

Volume: 13, P: 5
Cooperative crosstalk

Sarah Seton-Rogers
Research Highlights24 Mar 2015
Nature Reviews Cancer

Volume: 15, P: 198
Domino effect

Joan Massagué and colleagues have identified a paracrine signalling network between tumour and stromal cells in breast cancer that seems to drive both metastasis and resistance to chemotherapy.

Sarah Seton-Rogers
Research Highlights24 Jul 2012
Nature Reviews Cancer

Volume: 12, P: 506
Connecting androgen receptor and immunity

Sarah Seton-Rogers
Research Highlights26 Apr 2016
Nature Reviews Cancer

Volume: 16, P: 273
All in the family

Sarah Seton-Rogers
Research Highlights01 Mar 2007
Nature Reviews Cancer

Volume: 7, P: 158
A lethal storm

Sarah Seton-Rogers
Research Highlights24 Nov 2014
Nature Reviews Cancer

Volume: 14, P: 766
Diabetes treatment and intestinal tumorigenesis

Sarah Seton-Rogers
Research Highlights24 Mar 2015
Nature Reviews Cancer

Volume: 15, P: 198
Staying Power

Sarah Seton-Rogers
News01 Jul 2006
Nature Reviews Cancer

Volume: 6, P: 490
Chimeric expression

Sarah Seton-Rogers
Research Highlights22 Feb 2013
Nature Reviews Cancer

Volume: 13, P: 149
Less is more

Sarah Seton-Rogers
Research Highlights01 Feb 2007
Nature Reviews Drug Discovery

Volume: 6, P: 112
Tissue-specific functions

Sarah Seton-Rogers
Research Highlights17 Oct 2013
Nature Reviews Cancer

Volume: 13, P: 757
Nuclear PTEN

Sarah Seton-Rogers
Research Highlights23 Aug 2013
Nature Reviews Cancer

Volume: 13, P: 606
Catabolic effects

A recentNaturepaper identifies a catabolite of tryptophan as an endogenous ligand of aryl hydrocarbon receptor and links this pathway to tumorigenesis and suppression of antitumour immunity.

Sarah Seton-Rogers
Research Highlights24 Oct 2011
Nature Reviews Cancer

Volume: 11, P: 757