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Natural and inducible T_H17 cells are regulated differently by Akt and mTOR pathways

The Akt-mTOR axis influences cell activation, differentiation and metabolism. Jordan and colleagues show that thymic and inducible T_H17 cells exhibit different requirements for mTORC1 and mTORC2 as well as Akt isoforms.

Jiyeon S Kim
Tammarah Sklarz
Gary A Koretzky
Research05 May 2013
Nature Immunology

Volume: 14, P: 611-618
Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response

Sarah J. Skuli
A’ishah Bakayoko
Martin Carroll
ResearchOpen Access09 Jul 2025
Leukemia

Volume: 39, P: 2087-2098
Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites

How autophagy supports tumor cell metabolism is not fully clear. Here, the authors show that autophagy regulates lipid availability to support mitochondrial oxidative metabolism through mitochondria-endoplasmic reticulum contact sites, necessary for cell proliferation in AML.

Claudie Bosc
Nicolas Broin
Carine Joffre
ResearchOpen Access13 Aug 2020
Nature Communications

Volume: 11, P: 1-14

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