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Showing 151–169 of 169 results
Advanced filters: Author: Sarah Teichmann Clear advanced filters
  • This Perspective outlines the Human Developmental Cell Atlas initiative, which uses state-of-the-art technologies to map and model human development across gestation, and discusses the early milestones that have been achieved.

    • Muzlifah Haniffa
    • Deanne Taylor
    • Matthias Zilbauer
    Reviews
    Nature
    Volume: 597, P: 196-205
  • In this Perspective, Börner et al. discuss initiatives by 16 consortia to construct a Human Reference Atlas (HRA) comprising reference organs linked to tables that name major anatomical structures, cell types, plus biomarkers (ASCT+B) and present examples of HRA usage.

    • Katy Börner
    • Sarah A. Teichmann
    • Griffin Weber
    Reviews
    Nature Cell Biology
    Volume: 23, P: 1117-1128
  • The Human BioMolecular Atlas Program (HuBMAP) presents its production phase: the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

    • Sanjay Jain
    • Liming Pei
    • Michael P. Snyder
    Reviews
    Nature Cell Biology
    Volume: 25, P: 1089-1100
  • Diversity is a creative force that broadens views and enhances ideas; it increases productivity as well as the impact of our science, making our respective organisations more agile and timely. Equality of opportunity is a key to success for any research organisation. Here we argue that every research organisation, whether in academia or in industry, needs to have better inclusion policies to harness the benefits of diversity in research. Drawing from our personal experiences and perspectives as women in science, we share our suggestions on how to promote inclusion in academia and create a better research culture for all. Our shared experiences highlight the many hurdles women in science face on a daily basis. We stress that rules and regulations, as well as education for awareness, will play critical role in this much needed shift from a male-dominated scientific culture that dates from Victorian times to a modern focus on gender equality in science. The key ingredients of this new culture will be flexibility, transparency, fairness and thoughtfulness.

    • Sarah A. Teichmann
    • Muzlifah Haniffa
    • Jasmin Fisher
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 13, P: 1-6
  • A single-cell atlas of the human musculoskeletal system could help to improve the understanding of musculoskeletal function in growth, homeostasis, ageing and disease. This Roadmap delineates the steps required and challenges involved in creating such an atlas.

    • Mathew Baldwin
    • Christopher D. Buckley
    • Sarah Snelling
    Reviews
    Nature Reviews Rheumatology
    Volume: 19, P: 738-752
  • Single-cell transcriptomics is beginning to systematically define commonalities but also heterogeneity within and between organs for multiple human cell types. Here, the authors review emerging biological insights from cross-tissue single-cell transcriptomic studies into epithelial, fibroblast, vascular and immune cells.

    • Rasa Elmentaite
    • Cecilia Domínguez Conde
    • Sarah A. Teichmann
    Reviews
    Nature Reviews Genetics
    Volume: 23, P: 395-410
  • The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe.

    • Nikolaus Rajewsky
    • Geneviève Almouzni
    • Frauke Zipp
    Reviews
    Nature
    Volume: 587, P: 377-386
  • In this protocol, the authors describe two automated versions of the Smart-seq2 method for full-length single-cell RNA sequencing: a medium-throughput variant using off-the-shelf reagents and a high-throughput version using a commercially available kit.

    • Lira Mamanova
    • Zhichao Miao
    • Sarah A. Teichmann
    Protocols
    Nature Protocols
    Volume: 16, P: 2886-2915
  • The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles.

    • Marie-Christine Birling
    • Atsushi Yoshiki
    • Stephen A. Murray
    Comments & Opinion
    Nature Genetics
    Volume: 53, P: 416-419
  • An increasing number of multifactorial diseases have been linked to intestinal dysbiosis — that is, changes in the composition and function of the gut microbiome. Here, the authors explore the causes and consequences of dysbiosis, and discuss implications for the aetiology and treatment of many common immune-mediated diseases.

    • Maayan Levy
    • Aleksandra A. Kolodziejczyk
    • Eran Elinav
    Reviews
    Nature Reviews Immunology
    Volume: 17, P: 219-232