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Sphingosine-1-phosphate suppresses GLUT activity through PP2A and counteracts hyperglycemia in diabetic red blood cells

Red blood cells (RBC) carry the majority of sphingosine-1-phosphate (S1P). Here, the authors show that RBC dynamically regulate S1P levels in response to metabolic stress and employ them to regulate glucose uptake, glycolysis and the pentose phosphate pathway as protection against lipid peroxidation.

Nadine Thomas
Nathalie H. Schröder
Bodo Levkau
ResearchOpen Access14 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction

Antiplatelet medication is standard care in myocardial infarction (MI). Here, the authors show that platelets release bioactive sphingosine-1- phosphate (S1P) during MI to protect the heart against injury, and that certain antiplatelet drugs preserve this favourable S1P release, while others don’t.

Amin Polzin
Lisa Dannenberg
Bodo Levkau
ResearchOpen Access26 Apr 2023
Nature Communications

Volume: 14, P: 1-11
Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss

Promoting more bone growth is of keen interest in the treatment of osteoporosis, and preventing the degradation of S1P offers a new therapeutic avenue for this approach.

Sarah Weske
Mithila Vaidya
Bodo Levkau
Research16 Apr 2018
Nature Medicine

Volume: 24, P: 667-678

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