Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Saredo Said Clear advanced filters
  • It is uncertain how much life expectancy of the Chinese population would improve under current and greater policy targets on lifestyle-based risk factors for chronic diseases and mortality behaviours. Here we report a simulation of how improvements in four risk factors, namely smoking, alcohol use, physical activity and diet, could affect mortality. We show that in the ideal scenario, that is, all people who currently smokers quit smoking, excessive alcohol userswas reduced to moderate intake, people under 65 increased moderate physical activity by one hour and those aged 65 and older increased by half an hour per day, and all participants ate 200 g more fresh fruits and 50 g more fish/seafood per day, life expectancy at age 30 would increase by 4.83 and 5.39 years for men and women, respectively. In a more moderate risk reduction scenario referred to as the practical scenario, where improvements in each lifestyle factor were approximately halved, the gains in life expectancy at age 30 could be half those of the ideal scenario. However, the validity of these estimates in practise may be influenced by population-wide adherence to lifestyle recommendations. Our findings suggest that the current policy targets set by the Healthy China Initiative could be adjusted dynamically, and a greater increase in life expectancy would be achieved.

    • Qiufen Sun
    • Liyun Zhao
    • Chan Qu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • Many recent proteomics studies use either Olink or SomaScan platforms to quantify proteins in high-throughput, but the consistency between the two is unclear. Here, the authors measure proteins in the same samples using both platforms, finding only modest correlation, and compare associations with genetic variants and disease.

    • Baihan Wang
    • Alfred Pozarickij
    • Zhengming Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Inflammation is associated with a variety of diseases. Here, the authors identify 266 genetic loci associated with C-reactive protein levels, a marker of inflammation, in >500,000 Europeans, along with associated pathways, clinical outcomes and potential causal associations with disease.

    • Saredo Said
    • Raha Pazoki
    • Abbas Dehghan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10
  • Chronic inflammation and lipometabolism share many causal genes and possibly pathways. Here, the authors use a multi-trait GWAS approach to study shared genetic determinants of low-grade inflammation, measured by C-reactive protein (CRP), and closely linked lipid and metabolic pathways.

    • Fotios Koskeridis
    • Evangelos Evangelou
    • Ioanna Tzoulaki
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11
  • Plasma levels of liver enzymes provide insights into hepatic function and related diseases. Here, the authors perform a genome-wide association study on three liver enzymes, identifying genetic variants associated with their plasma concentration as well as links to metabolic and cardiovascular diseases.

    • Raha Pazoki
    • Marijana Vujkovic
    • Rachel B. Ramoni
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12
  • Observational analyses from the China Kadoorie Biobank found that alcohol consumption was associated with higher risks of 61 diseases in Chinese men, with most of these associations confirmed by genetic analyses.

    • Pek Kei Im
    • Neil Wright
    • Xiaoyi Zhang
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 1476-1486