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Showing 1–2 of 2 results
Advanced filters: Author: Sascha Wani Clear advanced filters

  • By probing the essentiality of diverse genes encoding mRNA translation factors in different human cell types using CRISPR interference screens, Rodschinka et al. discover that human stem cells critically depend on proteins rescuing stalled or collided ribosomes.

    • Geraldine Rodschinka
    • Sergio Forcelloni
    • Danny D. Nedialkova
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 1932-1946

  • Using modification-induced misincorporation tRNA sequencing, Gao and Behrens find that on differentiation, reduced mTORC1 signalling activates MAF1, which restricts RNA polymerase III to human tRNA housekeeping genes, to ensure that tRNA anticodon pools remain stable.

    • Lexi Gao
    • Andrew Behrens
    • Danny D. Nedialkova
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 100-112