Nature Search

Enzymatic synthesis of key RNA therapeutic building blocks using simple phosphate donors

Nucleoside triphosphates (NTPs) are important building blocks that underpin emerging enzymatic approaches to RNA therapeutics manufacturing. Here, authors develop a biocatalytic strategy to convert nucleosides into NTPs containing clinically relevant modifications, using simple phosphate donors.

Qinglong Meng
Caecilie Benckendorff
Sarah L. Lovelock
ResearchOpen Access17 Dec 2025
Nature Communications

Volume: 17, P: 1-11
Quantitative evolutionary dynamics using high-resolution lineage tracking

Random DNA barcodes were used to simultaneously track hundreds of thousands of lineages in large cell populations, revealing deterministic dynamics early in their evolution.

Sasha F. Levy
Jamie R. Blundell
Gavin Sherlock
Research25 Feb 2015
Nature

Volume: 519, P: 181-186
Temporal structure of natural language processing in the human brain corresponds to layered hierarchy of large language models

The way in which the brain processes language from a collection of sounds to meaningful concepts remains poorly understood. Here, the authors show that the brain’s temporal responses to speech closely follow the layer-by-layer progression of LLMs, revealing shared computational principles.

Ariel Goldstein
Eric Ham
Uri Hasson
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-12
High-resolution lineage tracking reveals travelling wave of adaptation in laboratory yeast

A renewable barcoding system reveals the evolutionary dynamics of laboratory budding yeast, showing that fitness changes over time in a travelling wave of adaptation that can fluctuate owing to leapfrogging events.

Alex N. Nguyen Ba
Ivana Cvijović
Michael M. Desai
Research13 Nov 2019
Nature

Volume: 575, P: 494-499
A scalable double-barcode sequencing platform for characterization of dynamic protein-protein interactions

Protein-protein interactions (PPIs) play a major role in defining biological functions. Here, the authors present PPiSeq, a method to quantitatively score dynamic PPIs in yeast combining fragment complementation assays, genomic double-barcoding, and an analytical framework to precisely call fitness from barcode lineage trajectories.

Ulrich Schlecht
Zhimin Liu
Sasha F. Levy
ResearchOpen Access25 May 2017
Nature Communications

Volume: 8, P: 1-9
Genome-scale analysis of interactions between genetic perturbations and natural variation

Here the authors investigate the interactions between genetic perturbations and segregating loci on a genome scale in yeast using barcoded CRISPRi. Strains’ responses to perturbations are shaped by perturbation-locus interactions that cannot be measured by examining perturbations or natural variation alone.

Joseph J. Hale
Takeshi Matsui
Ian M. Ehrenreich
ResearchOpen Access18 May 2024
Nature Communications

Volume: 15, P: 1-15
Mandated on-site wastewater reuse in San Francisco: the role of distributive fairness for policy acceptance

Josianne Kollmann
Sasha Harris-Lovett
Nadja Contzen
ResearchOpen Access19 Nov 2025
npj Urban Sustainability

Volume: 5, P: 1-10
The dynamics of adaptive genetic diversity during the early stages of clonal evolution

Lineage tracking of barcoded Saccharomyces cerevisiae growing in nutrient-limited conditions finds that a predictable increase in genetic diversity through single-mutant lineages is followed by a crash in diversity, owing to the success of highly fit double mutants.

Jamie R. Blundell
Katja Schwartz
Sasha F. Levy
Research31 Dec 2018
Nature Ecology & Evolution

Volume: 3, P: 293-301
The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross

Heritable traits can be affected by additive, dominance, and epistatic effects at genetic loci. Here, the authors use chromosomally-encoded barcodes to perform linkage mapping in diploid cross progeny in budding yeast, finding that epistasis in diploids frequently modifies both additivity and dominance.

Takeshi Matsui
Martin N. Mullis
Ian M. Ehrenreich
ResearchOpen Access18 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Shared computational principles for language processing in humans and deep language models

Deep language models have revolutionized natural language processing. The paper discovers three computational principles shared between deep language models and the human brain, which can transform our understanding of the neural basis of language.

Ariel Goldstein
Zaid Zada
Uri Hasson
ResearchOpen Access07 Mar 2022
Nature Neuroscience

Volume: 25, P: 369-380
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Stop this waste of people, animals and money

Predatory journals have shoddy reporting and include papers from wealthy nations, find David Moher, Larissa Shamseer, Kelly Cobey and colleagues.

David Moher
Larissa Shamseer
Hedyeh Ziai
Comments & Opinion07 Sept 2017
Nature

Volume: 549, P: 23-25
Immunogenicity of COVID-19 booster vaccines in children receiving immunosuppressive medications

Janna R. Shapiro
Florence Choi
Ruud H. J. Verstegen
Research21 Jul 2025
Pediatric Research

P: 1-11

Search

Filter By:

Search

Quick links