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Showing 1–3 of 3 results
Advanced filters: Author: Sashika Richards Clear advanced filters

  • The Malaria parasite’s chloroquine resistance transporter is a polyspecific peptide transporter linked to multidrug resistance. The authors identify drug & substrate binding sites, and explain substrate diversity and the fitness cost of resistance.

    • John D. Tanner
    • Sashika N. Richards
    • Ben Corry
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al. show that PfCRT transports host-derived peptides of 4-11 residues but not other ions or metabolites, and that drug-resistance-conferring PfCRT mutants have reduced peptide transport.

    • Sarah H. Shafik
    • Simon A. Cobbold
    • Rowena E. Martin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Roquin is an RNA-binding protein that promotes the degradation of specific mRNAs and is crucial for the maintenance of peripheral immune tolerance. Here the authors show that, in addition to its target mRNAs, Roquin can bind miR-146a and the RISC component Ago2 to control homeostasis of both RNA species.

    • Monika Srivastava
    • Guowen Duan
    • Carola G. Vinuesa
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13