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Advanced filters: Author: Saskia Heybrock Clear advanced filters

Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export

Cholesterol transport is tightly regulated in the cell and in lysosomes is regulated by NPC1/2. Here, Heybrock et al. use molecular modeling, knockout mice and cell based studies to show that LIMP-2 also mediates lysosomal cholesterol transport.

Saskia Heybrock
Kristiina Kanerva
Dante Neculai
ResearchOpen Access06 Aug 2019
Nature Communications

Volume: 10, P: 1-12
Sphingosine-1-phosphate signalling activates E-Syt1 to facilitate HDL-derived cholesterol transport

Xu, Meng, St-Germain et al. report that S1P in HDL induces a calcium signalling cascade involving E-Syt1 that ultimately promotes the formation of contact sites between the endoplasmic reticulum and the plasma membrane, as well as HDL-derived cholesterol transport.

Zizhen Xu
Ying Meng
Dante Neculai
Research28 May 2025
Nature Cell Biology

Volume: 27, P: 918-930
Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies

Lysosomal integral membrane protein-2 (LIMP-2) is a glucocerebrosidase receptor, which is linked to kidney failure and other diseases. Here the authors show that LIMP-2 is also a phospholipid receptor and present the lipid-bound structure of the LIMP-2 luminal domain dimer and discuss its lipid trafficking mechanism.

Karen S. Conrad
Ting-Wen Cheng
Michael D. Ehlers
ResearchOpen Access04 Dec 2017
Nature Communications

Volume: 8, P: 1-13

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