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Showing 1–6 of 6 results
Advanced filters: Author: Saskia Hutten Clear advanced filters

  • Here, the authors present the crystal structure of Transportin 3 (TNPO3) bound to its cargo cold-inducible RNA-binding protein (CIRBP), uncovering a distinct mechanism of protein nuclear import regulation independent of phosphorylation.

    • Qishun Zhou
    • Theo Sagmeister
    • Tobias Madl
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Asymmetric subcellular mRNA distribution is important for local translation of neuronal mRNAs. Here the authors employed MS2 live-cell imaging and showed that the reporter mRNA containing the 3’ UTR of Rgs4 shows an anterograde transport bias, dependent on neuronal activity and the protein Staufen2, and mediates sustained mRNA recruitment to synapses.

    • Karl E. Bauer
    • Inmaculada Segura
    • Michael A. Kiebler
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Processing bodies (P-bodies) are non-membrane-bound protein/RNA granules in the cytosol. Here the authors combine bioinformatics, NMR and cell based assays and find that lysine is enriched in the disordered regions of P-body-associated proteins and show that lysine-rich polypeptides form highly dynamic lysine/RNA-coacervates and lysine acetylation reverses liquid-liquid phase separation.

    • Tina Ukmar-Godec
    • Saskia Hutten
    • Markus Zweckstetter
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Repeat-associated non-AUG (RAN) translation generates toxic repeat proteins from pathological repeat expansions found in certain neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal dementia. How to suppress RAN translation has so far been unknown. A new study now reports a selective regulator of RAN translation identified in a genetic screen in yeast.

    • Saskia Hutten
    • Dorothee Dormann
    News & Views
    Nature Neuroscience
    Volume: 22, P: 1379-1380