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Showing 1–8 of 8 results
Advanced filters: Author: Sathi Wijeyesinghe Clear advanced filters

  • Notch signaling promotes the maintenance of lung-resident CD8+ memory T cells that are transcriptionally poised for rapid effector responses but have heightened expression of inhibitory receptors, suggestive of tight regulation.

    • Sathi Wijeyesinghe
    • David Masopust
    News & Views
    Nature Immunology
    Volume: 17, P: 1337-1338

  • Investigations in mice using parabiosis and cohousing experiments reveal that nonlymphoid organs serve as reservoirs of tissue-autonomous cellular immunity, leading to the decentralization of organism-level immune homeostasis.

    • Sathi Wijeyesinghe
    • Lalit K. Beura
    • David Masopust
    Research
    Nature
    Volume: 592, P: 457-462

  • The immunosuppressive tumor environment and the lack of functional anti-tumor immunity are major limiting factors in immunotherapy. Here the authors show that human and mouse tumors are infiltrated by virus-specific memory T cells, which can be harnessed by viral peptides to induce local and systemic anti-tumor immunity and synergize with checkpoint blockade.

    • Pamela C. Rosato
    • Sathi Wijeyesinghe
    • David Masopust
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • The function of B cells in peripheral blood and secondary lymphoid organs has long been appreciated but whether and how they contribute to tissue immune homeostasis is lesser known. Non-lymphoid organs harbour tissue-resident B cells that include a substantial population of B-1 cells and promote homeostatic anti-inflammatory macrophage polarization via IL-10, with profound effects on bacterial clearance during local infection.

    • Ondrej Suchanek
    • John R. Ferdinand
    • Menna R. Clatworthy
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • Tissue-resident memory (TRM) cells are generally stably maintained in discrete tissues or organs. Masopust and colleagues show that TRM cells can reenter the circulation, and exhibit considerable plasticity, although they retain a proclivity to reestablish themselves in their tissue of origin.

    • Raissa Fonseca
    • Lalit K. Beura
    • David Masopust
    Research
    Nature Immunology
    Volume: 21, P: 412-421

  • The cytokine TGF-β maintains the residency of cells of the immune system in barrier tissues. Kaplan and colleagues demonstrate that specific integrins expressed by epithelial cells activate latent TGF-β and that this is critical to maintain residency of cells of the immune system in the skin and gut.

    • Javed Mohammed
    • Lalit K Beura
    • Daniel H Kaplan
    Research
    Nature Immunology
    Volume: 17, P: 414-421