Nature Search

Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation

Here the authors show that active DNA damage response signaling is required both to initiate and maintain meiotic sex chromosome inactivation via a dynamic and reversible process.

Hironori Abe
Yu-Han Yeh
Satoshi H. Namekawa
ResearchOpen Access28 Nov 2022
Nature Communications

Volume: 13, P: 1-18
Attenuated chromatin compartmentalization in meiosis and its maturation in sperm development

Hi-C analyses of meiotic and postmeiotic male germ cells show that global reprogramming of 3D chromatin organization gives rise to the highly compartmentalized genome architecture seen in mature sperm.

Kris G. Alavattam
So Maezawa
Satoshi H. Namekawa
Research18 Feb 2019
Nature Structural & Molecular Biology

Volume: 26, P: 175-184
Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition

The mapping of super-enhancers (SEs) in four stages of spermatogenesis reveals how meiotic enhancers remain ‘poised’ for activation as spermatogonia enter meiosis.

So Maezawa
Akihiko Sakashita
Satoshi H. Namekawa
Research07 Sept 2020
Nature Structural & Molecular Biology

Volume: 27, P: 978-988
CTCF-mediated 3D chromatin sets up the gene expression program in the male germline

Here the authors determine the high-resolution 3D chromatin architecture of mouse male germ cells during spermatogenesis and show that CTCF-mediated 3D chromatin dictates the gene expression program required for spermatogenesis.

Yuka Kitamura
Kazuki Takahashi
Satoshi H. Namekawa
Research03 Mar 2025
Nature Structural & Molecular Biology

Volume: 32, P: 1227-1240
Endogenous retroviruses drive species-specific germline transcriptomes in mammals

ERV-specific enhancer-based networks regulate species-specific transcriptomes in mammalian spermatogenesis.

Akihiko Sakashita
So Maezawa
Satoshi H. Namekawa
Research07 Sept 2020
Nature Structural & Molecular Biology

Volume: 27, P: 967-977
ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network

Here, the authors show that ZBTB16, SALL4 and SOX3 regulate mouse stem cell renewal and sperm production through a three-dimensional interacting chromatin network that maintains undifferentiated spermatogonia and primes genes for spermatogonia development and meiosis.

Chongil Yi
Yuka Kitamura
Bradley R. Cairns
ResearchOpen Access03 Mar 2025
Nature Structural & Molecular Biology

Volume: 32, P: 1213-1226
Genetic insights into biological mechanisms governing human ovarian ageing

Hundreds of genetic loci associated with age at menopause, combined with experimental evidence in mice, highlight mechanisms of reproductive ageing across the lifespan.

Katherine S. Ruth
Felix R. Day
John R. B. Perry
Research04 Aug 2021
Nature

Volume: 596, P: 393-397
Intravenous nicardipine for Japanese patients with acute intracerebral hemorrhage: an individual participant data analysis

Kazunori Toyoda
Sohei Yoshimura
Kazuo Minematsu
ResearchOpen Access13 Oct 2022
Hypertension Research

Volume: 46, P: 75-83
PRC1-mediated epigenetic programming is required to generate the ovarian reserve

In humans, the ovarian reserve is maintained over decades by meiotic arrest of oocytes. Here the authors show that Polycomb Repressive Complex 1 (PRC1)-mediated epigenetic programming is essential for formation of ovarian reserve and thus female reproductive lifespan.

Mengwen Hu
Yu-Han Yeh
Satoshi H. Namekawa
ResearchOpen Access10 Aug 2022
Nature Communications

Volume: 13, P: 1-10
UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells

Retrotransposons are silenced by an epigenetic mechanism and piRNA pathway in the mammalian germline. Here, the authors report that UHRF1 suppresses retrotransposons by interacting with PRMT5 and PIWI proteins during spermatogenesis.

Juan Dong
Xiaoli Wang
Shuiqiao Yuan
ResearchOpen Access17 Oct 2019
Nature Communications

Volume: 10, P: 1-14
BRUCE preserves genomic stability in the male germline of mice

Lixiao Che
Kris G. Alavattam
Chunying Du
Research05 Mar 2020
Cell Death & Differentiation

Volume: 27, P: 2402-2416
Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes

DNMT3A is known to methylate DNA at histone H3 lysine 36 (H3K36me3)-marked transcriptionally active regions in mouse oocytes. Here the authors show that DNMT3A is also guided by H3K36me2 to methylate broad domains in genic and intergenic loci, as well as on the X chromosome. These two histone marks together comprise the minimal chromatin signature for global DNA methylation in mouse oocytes.

Seiichi Yano
Takashi Ishiuchi
Hiroyuki Sasaki
ResearchOpen Access03 Aug 2022
Nature Communications

Volume: 13, P: 1-12
Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis

The authors add to our knowledge of the transcriptional regulation of the meiotic program in mice spermatocytes, showing ZFP541 regulates meiotic prophase and transition to the division phase by being the target for upstream factors MEIOSIN/STRA8.

Yuki Horisawa-Takada
Chisato Kodera
Kei-Ichiro Ishiguro
ResearchOpen Access01 Jun 2021
Nature Communications

Volume: 12, P: 1-17
Detection of nascent RNA, single-copy DNA and protein localization by immunoFISH in mouse germ cells and preimplantation embryos

Satoshi H Namekawa
Jeannie T Lee
Protocols10 Feb 2011
Nature Protocols

Volume: 6, P: 270-284
PRC1 suppresses a female gene regulatory network to ensure testicular differentiation

So Maezawa
Masashi Yukawa
Satoshi H. Namekawa
ResearchOpen Access04 Aug 2023
Cell Death & Disease

Volume: 14, P: 1-12
UHRF1 establishes crosstalk between somatic and germ cells in male reproduction

Yanqing Wu
Peng Duan
Shuiqiao Yuan
ResearchOpen Access19 Apr 2022
Cell Death & Disease

Volume: 13, P: 1-13
Functional inhibition of cancer stemness-related protein DPP4 rescues tyrosine kinase inhibitor resistance in renal cell carcinoma

Shuhei Kamada
Takeshi Namekawa
Satoshi Inoue
Research10 May 2021
Oncogene

Volume: 40, P: 3899-3913
Broad H3K4me3 domains orchestrate temporal control of gene expression

Yuka Kitamura
Mengwen Hu
Satoshi H. Namekawa
Research Highlights25 Mar 2025
Cell Research

Volume: 35, P: 322-323
Fancb deficiency impairs hematopoietic stem cell function

Wei Du
Surya Amarachintha
Qishen Pang
ResearchOpen Access11 Dec 2015
Scientific Reports

Volume: 5, P: 1-11
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang
Wei Du
Qishen Pang
ResearchOpen Access05 Apr 2017
Scientific Reports

Volume: 7, P: 1-11
Parental competition for the regulators of chromatin dynamics in mouse zygotes

Quantification of chromatin dynamics in paternal and maternal pronuclei reveals opposite effects on chromatin dynamics by oocyte- and sperm derived factors.

Masatoshi Ooga
Rei Inoue
Teruhiko Wakayama
ResearchOpen Access14 Jul 2022
Communications Biology

Volume: 5, P: 1-9
Testis-expressed gene 11 inhibits cisplatin-induced DNA damage and contributes to chemoresistance in testicular germ cell tumor

Sachi Kitayama
Kazuhiro Ikeda
Kuniko Horie
ResearchOpen Access01 Nov 2022
Scientific Reports

Volume: 12, P: 1-12

Search

Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation

Attenuated chromatin compartmentalization in meiosis and its maturation in sperm development

Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition

CTCF-mediated 3D chromatin sets up the gene expression program in the male germline

Endogenous retroviruses drive species-specific germline transcriptomes in mammals

ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network

Genetic insights into biological mechanisms governing human ovarian ageing

Intravenous nicardipine for Japanese patients with acute intracerebral hemorrhage: an individual participant data analysis

PRC1-mediated epigenetic programming is required to generate the ovarian reserve

UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells

BRUCE preserves genomic stability in the male germline of mice

Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes

Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis

Detection of nascent RNA, single-copy DNA and protein localization by immunoFISH in mouse germ cells and preimplantation embryos

PRC1 suppresses a female gene regulatory network to ensure testicular differentiation

UHRF1 establishes crosstalk between somatic and germ cells in male reproduction

Functional inhibition of cancer stemness-related protein DPP4 rescues tyrosine kinase inhibitor resistance in renal cell carcinoma

Broad H3K4me3 domains orchestrate temporal control of gene expression

Fancb deficiency impairs hematopoietic stem cell function

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Parental competition for the regulators of chromatin dynamics in mouse zygotes

Testis-expressed gene 11 inhibits cisplatin-induced DNA damage and contributes to chemoresistance in testicular germ cell tumor

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