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Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19

Cytotoxic T lymphocytes play important roles in the anti-viral immune response in COVID-19, and it is important to know how they contribute to disease outcome. Authors here identify a dominant SARS-CoV-2 M protein epitope, M_198–206, and show that M_198–206-specific cytotoxic T cells from convalescent patients with severe disease harbour a gene expression pattern indicative of poor functionality.

Hideki Ogura
Jin Gohda
Satoshi Ishido
ResearchOpen Access16 Dec 2022
Nature Communications

Volume: 13, P: 1-15
The efficacy and safety of multi-loop traction device for gastric endoscopic submucosal dissection: a single center prospective pilot study

Gen Kitahara
Toru Kaneko
Chika Kusano
ResearchOpen Access16 Nov 2023
Scientific Reports

Volume: 13, P: 1-8
March1-dependent modulation of donor MHC II on CD103⁺ dendritic cells mitigates alloimmunity

Donor-derived dendritic cells (do-DC) in the graft can contribute to the induction of alloimmunity and tissue rejection, but how do-DC can be targeted for improving graft survival is unclear. Here the authors show that reducing MHC-II expression on do-DCs by DnaK pre-treatment can decrease the priming of alloimmunity and prolong graft survival in mouse models.

Thiago J. Borges
Naoka Murakami
Cristina Bonorino
ResearchOpen Access28 Aug 2018
Nature Communications

Volume: 9, P: 1-15
Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells

The antigen-presenting abilities of plasmacytoid dendritic cells (DCs) are not well characterized. Villadangos and colleagues show that unlike conventional DCs, plasmacytoid DCs continue to synthesize and degrade MHC class II molecules, and thereby present endogenous viral antigen, after activation.

Louise J Young
Nicholas S Wilson
Jose A Villadangos
Research12 Oct 2008
Nature Immunology

Volume: 9, P: 1244-1252
Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation

Takeda et al. investigate the role of mitochondrial ubiquitin ligase (MITOL) in Alzheimer’s disease progression. They demonstrate that MITOL has a direct effect on mitochondrial dynamics and functioning and its ablation can enhance the seeding effect of Aβ-plaques, leading to cognitive decline in the transgenic mice model of Alzheimer’s disease.

Keisuke Takeda
Aoi Uda
Shigeru Yanagi
ResearchOpen Access12 Feb 2021
Communications Biology

Volume: 4, P: 1-13
Caffeine protects against stress-induced murine depression through activation of PPARγC1α-mediated restoration of the kynurenine pathway in the skeletal muscle

Chongye Fang
Shuhei Hayashi
Jun Sheng
ResearchOpen Access31 Mar 2021
Scientific Reports

Volume: 11, P: 1-13

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Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19

The efficacy and safety of multi-loop traction device for gastric endoscopic submucosal dissection: a single center prospective pilot study

March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity

Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells

Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation

Caffeine protects against stress-induced murine depression through activation of PPARγC1α-mediated restoration of the kynurenine pathway in the skeletal muscle

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March1-dependent modulation of donor MHC II on CD103⁺ dendritic cells mitigates alloimmunity