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Author Correction: Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation

Chizuko Miyamoto
Satoshi Kojo
Takashi Ebihara
Amendments and CorrectionsOpen Access01 Mar 2019
Nature Communications

Volume: 10, P: 1
A mutant BCL11B-N440K protein interferes with BCL11A function during T lymphocyte and neuronal development

Taniuchi and colleagues describe the generation and phenotype of a mouse model carrying a defective Bcl11b allele encoding a mutant protein corresponding to BCL11B-N441K previously associated with human disease. They further characterize the molecular interactions between the mutant BCL11B protein and other transcription factors involved in early thymocyte development.

Kazuki Okuyama
Motoi Yamashita
Ichiro Taniuchi
Research01 Nov 2024
Nature Immunology

Volume: 25, P: 2284-2296
Downregulation of chemokine receptor 9 facilitates CD4⁺CD8αα⁺ intraepithelial lymphocyte development

Peripheral CD4⁺ T cells can develop into Intestinal intraepithelial lymphocytes (IEL) in the lamina propria. Here the authors characterise how IEL generation from CD4⁺ T cells is regulated and show using scRNA sequencing that Ccr9 is involved in this process through limiting IEL precursor differentiation.

Keiko Ono
Tomohisa Sujino
Takanori Kanai
ResearchOpen Access24 Aug 2023
Nature Communications

Volume: 14, P: 1-15
Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation

Group 2 innate lymphoid cells (ILC2) are important mediators for allergy, but how ILC2 are regulated under chronic inflammation is still unclear. Here the authors show that Runx transcription factors, which normally suppresses ILC2 activation at steady state, help promote ILC2 activation and type 2 cytokine production in lung allergy mouse models.

Chizuko Miyamoto
Satoshi Kojo
Takashi Ebihara
ResearchOpen Access25 Jan 2019
Nature Communications

Volume: 10, P: 1-13
Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity

CCL5 is an important chemokine for modulation of inflammatory responses, but how CCL5 expression is regulated is still unclear. Here the authors show that the CCL5 locus contains two enhancers, with the proximal enhancer being responsible for homeostatic expression and the distal enhancer enforcing inducibility, while both enhancers are modulated by RUNX3.

Wooseok Seo
Kanako Shimizu
Ichiro Taniuchi
ResearchOpen Access26 Mar 2020
Nature Communications

Volume: 11, P: 1-16
Alternative pathway for the development of V_α14⁺ NKT cells directly from CD4^–CD8^– thymocytes that bypasses the CD4⁺CD8⁺ stage

Natural killer T cells (NKT cells) are thought to originate at the double-positive stage of thymopoiesis. Taniguchi and colleagues find that a subset of NKT cells also appear earlier, at the double-negative stage, and that these give rise to liver-resident NKT cells with highly potent effector function.

Nyambayar Dashtsoodol
Tomokuni Shigeura
Masaru Taniguchi
Research30 Jan 2017
Nature Immunology

Volume: 18, P: 274-282
Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene

The commitment of helper and cytotoxic lineages for CD4 and CD8 T cells, respectively, is associated with the regulation of Cd4 gene expression. Here the authors show that an intronic silencer, S4, has differential effects and synergy with the RUNX complex to act on two enhancer elements of the CD4 gene to control T cell lineage commitment in the thymus.

Satoshi Kojo
Nighat Yasmin
Ichiro Taniuchi
ResearchOpen Access05 Sept 2018
Nature Communications

Volume: 9, P: 1-11
Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes

CD4 and CD8 T cells develop in the thymus with their transcription programs controlled by ThPOK and Runx3, respectively. Here the authors show that a pre-commitment event modulated by the transcription factor, Bcl11b, is required for the proper expression of ThPOK and Runx3 and correct CD4/CD8 lineage commitment.

Satoshi Kojo
Hirokazu Tanaka
Ichiro Taniuchi
ResearchOpen Access26 Sept 2017
Nature Communications

Volume: 8, P: 1-14
Improved non-relapse mortality in allogeneic hematopoietic stem cell transplantation: a long-standing multidisciplinary pursuit at a single center

Shuhei Kurosawa
Kairi Kojo
Noriko Doki
Correspondence20 May 2025
Bone Marrow Transplantation

Volume: 60, P: 1193-1195

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Author Correction: Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation

A mutant BCL11B-N440K protein interferes with BCL11A function during T lymphocyte and neuronal development

Downregulation of chemokine receptor 9 facilitates CD4⁺CD8αα⁺ intraepithelial lymphocyte development

Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation

Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity

Alternative pathway for the development of V_α14⁺ NKT cells directly from CD4^–CD8^– thymocytes that bypasses the CD4⁺CD8⁺ stage

Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene

Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes

Improved non-relapse mortality in allogeneic hematopoietic stem cell transplantation: a long-standing multidisciplinary pursuit at a single center

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