Nature Search

Signaling via Alk5 Controls Ontogeny of Lung Clara Cells

Yiming Xing
Changgong Li
Parviz Minoo
ResearchOpen Access08 Apr 2009
Nature Precedings

P: 1
Aging affects reprogramming of pulmonary capillary endothelial cells after lung injury in male mice

Here the authors report single-cell and spatial transcriptomics of young and aged male fibrotic mouse lungs. Age-related alterations in capillary sub-populations are associated with a proangiogenic phenotype linked to regeneration of the alveolar niche.

Marin Truchi
Marine Gautier-Isola
Bernard Mari
ResearchOpen Access06 Aug 2025
Nature Communications

Volume: 16, P: 1-21
Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis

Idiopathic pulmonary fibrosis is associated with myofibroblast activation in the lungs and metabolic alterations. Here, the authors show that the antidiabetic drug metformin has antifibrotic effects in human-derived samples and mouse models, by modulating a number of metabolic pathways to induce lipogenic transdifferentiation of myofibroblasts.

Vahid Kheirollahi
Roxana M. Wasnick
Elie El Agha
ResearchOpen Access05 Jul 2019
Nature Communications

Volume: 10, P: 1-16
Lung stem cells in the balance

Wnt ligands are secreted glycoproteins with critical roles in organogenesis, cancer initiation and progression, and maintenance of stem cell pluripotency. A new study strengthens considerably our understanding of the role of Wnt signaling in progenitor cells of the lung epithelium during development and injury.

Saverio Bellusci
News & Views01 Jul 2008
Nature Genetics

Volume: 40, P: 822-823
EVIDENCE FROM NORMAL EXPRESSION AND TARGETED MISEXPRESSION THAT BONE MORPHOGENETIC PROTEIN-4 (BMP-4) PLAYS A ROLE IN MOUSE LUNG MORPHOGENESIS.• 1992

Randall Henderson
Saverio Bellusci
Brigid L.M Hogan
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 335
FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis

De-pu Zhou
Lian-cheng Deng
Jin-San Zhang
ResearchOpen Access24 May 2023
Acta Pharmacologica Sinica

Volume: 44, P: 2004-2018
Fibroblast Growth Factor 10 Plays a Causative Role in the Tracheal Cartilage Defects in a Mouse Model of Apert Syndrome

Caterina Tiozzo
Stijn De Langhe
Saverio Bellusci
Research01 Oct 2009
Pediatric Research

Volume: 66, P: 386-390
Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation

The order of DNA methylation and histone modifications during transcription remained unclear. Here the authors show that HMGA2 induces DNA nicks at TGFB1-responsive genes, promoting nucleosome incorporation containing γ-H2AX, which is required for repair-mediated DNA demethylation and transcription.

Stephanie Dobersch
Karla Rubio
Guillermo Barreto
ResearchOpen Access16 Feb 2021
Nature Communications

Volume: 12, P: 1-20
Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a lethal disease with insufficient treatment strategies. Here the authors show that reduction of the microRNA MIRLET7D and hyperactivation of EP300 contribute to impaired epigenetic silencing by the MiCEE complex in pulmonary fibroblasts of IPF patients, and demonstrate the benefit of inhibiting EP300 for the treatment of IPF.

Karla Rubio
Indrabahadur Singh
Guillermo Barreto
ResearchOpen Access20 May 2019
Nature Communications

Volume: 10, P: 1-16
Molecular Mechanisms of Early Lung Specification and Branching Morphogenesis

David Warburton
Saverio Bellusci
Wei Shi
Research01 May 2005
Pediatric Research

Volume: 57, P: 26-37
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.

Martin G. Scherm
Isabelle Serr
Carolin Daniel
ResearchOpen Access13 Dec 2019
Nature Communications

Volume: 10, P: 1-15
Phenotype disruption of umbilical cord derived MSC by cyclic mechanical stretch and hyperoxia mediated by p21

Maurizio J. Goetz
Judith Behnke
Harald Ehrhardt
ResearchOpen Access07 Oct 2025
Scientific Reports

Volume: 15, P: 1-16
Anti-CCL2 therapy reduces oxygen toxicity to the immature lung

Tayyab Shahzad
Ying Dong
Harald Ehrhardt
ResearchOpen Access03 Jul 2024
Cell Death Discovery

Volume: 10, P: 1-12
TRAIL protects the immature lung from hyperoxic injury

Tayyab Shahzad
Cho-Ming Chao
Harald Ehrhardt
ResearchOpen Access15 Jul 2022
Cell Death & Disease

Volume: 13, P: 1-10
High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX

Indrabahadur Singh
Nihan Ozturk
Guillermo Barreto
Research05 Jun 2015
Cell Research

Volume: 25, P: 837-850

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