The precise regulation of mammalian body temperature is important for survival. Here the authors show that the peptidase nardilysin represses the transcription factor PGC-1α, and identify nardilysin as a regulator of basal body temperature, cold-induced thermogenesis and body insulation.
- Yoshinori Hiraoka
- Tatsuhiko Matsuoka
- Eiichiro Nishi
