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Showing 1–3 of 3 results
Advanced filters: Author: Sayma Zahid Clear advanced filters

  • DNA double-strand breaks endanger genome stability. Here, the authors present cryo-EM structures showing how Ku70/80 and DNA-PK bind DNA ends on nucleosomes, offering a mechanistic model for break recognition within chromatin.

    • Chloe Hall
    • Philippe Frit
    • Amanda K. Chaplin
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-13

  • Mycobacterium tuberculosis protein Ku is involved in DNA repair and a potential drug target. Here, using cryo-EM and complementary approaches, the authors obtain insights into Ku oligomerization and mechanisms of function in DNA synapsis.

    • Sayma Zahid
    • Sonia Baconnais
    • Amanda K. Chaplin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • The molecular basis for the enrollment of X family DNA polymerases in non-homologous end joining (NHEJ) is unclear. Here the authors elucidate the structure of Pol λ within the DNA-PK long-range complex and Pol μ in association with Ku70/80 and characterize the interaction between the BRCT domains of Pol λ and μ with Ku70/80.

    • Philippe Frit
    • Himani Amin
    • Amanda K. Chaplin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14