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Showing 1–4 of 4 results
Advanced filters: Author: Scott Frendo-Cumbo Clear advanced filters

  • Klingelhuber, Frendo-Cumbo et al. develop a proteomic atlas elucidating the intracellular spatiotemporal changes in protein levels and localizations during human adipogenesis.

    • Felix Klingelhuber
    • Scott Frendo-Cumbo
    • Natalie Krahmer
    ResearchOpen Access
    Nature Metabolism
    Volume: 6, P: 861-879

  • Lecoutre, Maqdasy and Rizo-Roca show that whole-body pharmacological inhibition or adipocyte-specific deletion of glutaminase in mice activates thermogenesis in inguinal adipocytes and promotes metabolic health. They also link decreased plasma and adipose tissue glutamine-to-glutamate ratios to insulin resistance in humans with obesity.

    • Simon Lecoutre
    • Salwan Maqdasy
    • Mikael Rydén
    ResearchOpen Access
    Nature Metabolism
    Volume: 6, P: 1329-1346

  • Single-cell studies of human white adipose tissue (WAT) provide insights into the specialized cell types in the tissue. Here the authors combine publicly available and newly generated high-resolution and bulk transcriptomic results from multiple human datasets to provide a comprehensive cellular map of white adipose tissue.

    • Lucas Massier
    • Jutta Jalkanen
    • Niklas Mejhert
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Maqdasy, Lecoutre et al. show that increased an phosphocreatine/creatine ratio in white adipocytes drives changes in AMP-activated protein kinase activity and promotes white adipocyte inflammation during obesity.

    • Salwan Maqdasy
    • Simon Lecoutre
    • Mikael Rydén
    ResearchOpen Access
    Nature Metabolism
    Volume: 4, P: 190-202