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Nature Aging (1)

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Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs

Kirkland et al. identify conserved age-dependent nuclear remodeling in Drosophila cardiomyocytes, dependent on declining Lamin C. They show that Lamin C loss induces reversible heart dysfunction by repressing myogenic transcription factors.

Natalie J. Kirkland
Scott H. Skalak
Adam J. Engler
Research22 Dec 2022
Nature Aging

Volume: 3, P: 17-33

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Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs

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