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Showing 1–7 of 7 results
Advanced filters: Author: Scott H. Soderling Clear advanced filters

  • The internal molecular mechanisms that underlie excitatory synaptogenesis remain poorly characterized. This study utilizes a chemogenetic approach, in vivo biotin identification (iBioID), to discover previously uncharacterized proteins at nascent synapses. CARMIL3 is identified as a cytoskeletal protein that facilitates spine maturation and AMPAR recruitment.

    • Erin F. Spence
    • Shataakshi Dube
    • Scott H. Soderling
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Protein interactions are essential for neural signaling and often perturbed in brain conditions. Here, the authors developed a CRISPR-based chemical-genetic approach to identify endogenous proximity proteomes that inform mechanism and phenotypic rescue strategies in mouse models of autism.

    • Yudong Gao
    • Daichi Shonai
    • Scott H. Soderling
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • A cell-surface fragment complementation strategy is used to identify the proteome at the junction of astrocytes and synapses in vivo, and shows that NRCAM expressed in astrocytes has a key role in regulating inhibitory synapse function.

    • Tetsuya Takano
    • John T. Wallace
    • Scott H. Soderling
    Research
    Nature
    Volume: 588, P: 296-302

  • This study identifies a mechanism linking loss of Arp2/3 to the progressive formation of shaft excitatory synaptic contacts. This leads to enhanced cortical excitation, striatal hyperdopaminergia and antipsychotic-responsive psychomotor agitation. This illustrates how diverse pathologies may converge downstream of spine actin disturbances to drive psychomotor behaviors.

    • Il Hwan Kim
    • Mark A Rossi
    • Scott H Soderling
    Research
    Nature Neuroscience
    Volume: 18, P: 883-891

  • Basal ganglia outputs to the superior colliculus are often associated with eye movements. Using in vivo recording and optogenetic stimulation, the authors demonstrate that a specific GABAergic pathway from the lateral substantia nigra pars reticulata to the lateral superior colliculus is critical for self-initiated drinking behavior, but not for whisking or blinking.

    • Mark A Rossi
    • Haofang E Li
    • Henry H Yin
    Research
    Nature Neuroscience
    Volume: 19, P: 742-748