Nature Search

P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips

Meta J. Kuehn
John Heuser
Scott J. Hultgren
Research19 Mar 1992
Nature

Volume: 356, P: 252-255
Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

Both F17-like and type 1 pili promote intestinal colonization in mouse colonic crypts, and the high-affinity mannoside M4284 reduces intestinal colonization of uropathogenic Escherichia coli while simultaneously treating urinary tract infections without disrupting the composition of the gut microbiota.

Caitlin N. Spaulding
Roger D. Klein
Scott J. Hultgren
Research14 Jun 2017
Nature

Volume: 546, P: 528-532
Vaccination with Acinetobacter baumannii adhesin Abp2D provides protection against catheter-associated urinary tract infection

Acinetobacter baumannii is a multi-drug-resistant pathogen of urgent international concern. Here, the authors develop a protein subunit vaccine which prevents A. baumannii catheter-associated urinary tract infections in mice by inhibiting Abp2D, a key adhesive virulence factor.

Morgan R. Timm
Kevin O. Tamadonfar
Scott J. Hultgren
ResearchOpen Access09 Aug 2025
Nature Communications

Volume: 16, P: 1-13
Urinary tract infections: epidemiology, mechanisms of infection and treatment options

Urinary tract infections (UTIs) pose a severe public health problem and are caused by a range of pathogens. In this Review, Hultgren and colleagues discuss how basic science studies are elucidating the molecular mechanisms of UTI pathogenesis and how this knowledge is being used for the development of novel clinical treatments for UTIs.

Ana L. Flores-Mireles
Jennifer N. Walker
Scott J. Hultgren
Reviews08 Apr 2015
Nature Reviews Microbiology

Volume: 13, P: 269-284
Author Correction: Longitudinal profiling of low-abundance strains in microbiomes with ChronoStrain

Younhun Kim
Colin J. Worby
Travis E. Gibson
Amendments and CorrectionsOpen Access29 May 2025
Nature Microbiology

Volume: 10, P: 1551
Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome

Uropathogenic Escherichia coli infection induces epigenetic remodelling and trained immune responses in bladder epithelial stem cells that affect susceptibility to recurrent infection.

Seongmi K. Russell
Jessica K. Harrison
Scott J. Hultgren
ResearchOpen Access10 Apr 2023
Nature Microbiology

Volume: 8, P: 875-888
Structural biology of the chaperone–usher pathway of pilus biogenesis

Chaperone–usher pili are assembled and secreted by a periplasmic chaperone and a dimeric outer-membrane usher complex. Gabriel Waksman and Scott Hultgren review the structural information that has been gathered over the past decade on the various players that participate in P and type 1 pilus biogenesis.

Gabriel Waksman
Scott J. Hultgren
Reviews12 Oct 2009
Nature Reviews Microbiology

Volume: 7, P: 765-774
Longitudinal profiling of low-abundance strains in microbiomes with ChronoStrain

ChronoStrain accurately profiles low-abundance strains in longitudinal samples by jointly modelling nucleotide sequencing errors, strain presence/absence and the temporal information associated with each sample using a differentiable Bayesian model.

Younhun Kim
Colin J. Worby
Travis E. Gibson
ResearchOpen Access06 May 2025
Nature Microbiology

Volume: 10, P: 1184-1197
Microbial co-occurrences on catheters from long-term catheterized patients

The authors examine temporal polymicrobial community composition in patients with long-term urinary catheters to identify species co-occurrences and demonstrate uropathogenic Escherichia coli augments growth of a prevalent opportunistic uropathogen in urine.

Taylor M. Nye
Zongsen Zou
Scott J. Hultgren
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Erratum: The biology and future prospects of antivirulence therapies

Lynette Cegelski
Garland R. Marshall
Scott J. Hultgren
Amendments and Corrections01 Nov 2009
Nature Reviews Microbiology

Volume: 7, P: 836
Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women

Multi-omics analyses of faecal, urine and blood samples from women with and without recurrent urinary tract infections reveal that gut dysbiosis and differential immune responses may play a role in risk of infection via the gut–bladder axis.

Colin J. Worby
Henry L. Schreiber IV
Ashlee M. Earl
Research02 May 2022
Nature Microbiology

Volume: 7, P: 630-639
A murine model of urinary tract infection

Chia-Suei Hung
Karen W Dodson
Scott J Hultgren
Protocols30 Jul 2009
Nature Protocols

Volume: 4, P: 1230-1243
Therapy for stressed bacteria

Bacteria oscillate between the planktonic and biofilm states through many hierarchically organized networks that respond to environmental cues. Recent research describes how a bacterial toxin-antitoxin system mediates this transition by controlling bacterial motility in response to extracellular stress.

Maria Hadjifrangiskou
Maria Kostakioti
Scott J Hultgren
News & Views17 May 2011
Nature Chemical Biology

Volume: 7, P: 345-347
Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes

Acinetobacter baumannii is generally considered an opportunistic pathogen. Here, Di Venanzio et al. develop a mouse model of catheter-associated urinary tract infection and show that a plasmid confers niche specificity to an A. baumannii urinary isolate by regulating the expression of chromosomal genes.

Gisela Di Venanzio
Ana L. Flores-Mireles
Mario F. Feldman
ResearchOpen Access24 Jun 2019
Nature Communications

Volume: 10, P: 1-13
Morphological plasticity as a bacterial survival strategy

Filamentation has been implicated in bacterial survival of exposure to environmental stresses, but in this Opinion, Sheryl S. Justice and colleagues propose that the morphological plasticity of pathogenic bacteria is a direct and adaptive response to the sensing of environmental changes.

Sheryl S. Justice
David A. Hunstad
Scott J. Hultgren
Reviews01 Feb 2008
Nature Reviews Microbiology

Volume: 6, P: 162-168
Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI

Catheter-associated urinary tract infections can often lead to secondary bloodstream infections, and catheter-induced bladder inflammation. In this work, authors utilise murine models to probe defective fibrinolysis drives extravascular fibrin formation, potentially predisposing hosts to severe CAUTI.

Jonathan J. Molina
Kurt N. Kohler
Ana L. Flores-Mireles
ResearchOpen Access27 Mar 2024
Nature Communications

Volume: 15, P: 1-16
Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection

In this work, the authors present E. coli PanSelect, a hybrid selection method for enriching E. coli from low-abundance microbiota, and apply it to stool samples from recurrent UTI sufferers, revealing distinct E. coli transcriptional profiles

Mark G. Young
Timothy J. Straub
Ashlee M. Earl
ResearchOpen Access02 Nov 2024
Nature Communications

Volume: 15, P: 1-15
The biology and future prospects of antivirulence therapies

Targeting bacterial virulence is an alternative approach to antimicrobial therapy. This Review considers recent efforts towards antivirulence-based drug discovery in the framework of marketable drugs, and discusses what challenges remain and the factors that are crucial to developing the antivirulence therapeutic approach.

Lynette Cegelski
Garland R. Marshall
Scott J. Hultgren
Reviews01 Jan 2008
Nature Reviews Microbiology

Volume: 6, P: 17-27
Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

Lynette Cegelski
Jerome S Pinkner
Scott J Hultgren
Research25 Oct 2009
Nature Chemical Biology

Volume: 5, P: 913-919
A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease

Previous Escherichia coli infection epigenetically alters host epithelial cell maturation and COX-2 mediated inflammation to predispose mice for future recurrent infection.

Valerie P. O'Brien
Thomas J. Hannan
Scott J. Hultgren
Research31 Oct 2016
Nature Microbiology

Volume: 2, P: 1-10
Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli

The crystal structure of the PapC usher, together with the PapDG chaperone–subunit complex, helps to elucidate the molecular mechanisms by which individual pilus subunits are assembled into larger P pili.

Natalie S. Omattage
Zengqin Deng
Scott J. Hultgren
Research01 Oct 2018
Nature Microbiology

Volume: 3, P: 1362-1368
Structural and energetic basis of folded-protein transport by the FimD usher

The crystal structure of the FimD usher traversed by the tip complex of a type 1 pilus demonstrates the mechanism by which pilus subunits are assembled and translocated during pilus elongation.

Sebastian Geibel
Erik Procko
Gabriel Waksman
Research10 Apr 2013
Nature

Volume: 496, P: 243-246
Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics

In this Review, Timm, Russell and Hultgren provide an overview of the bacterial and host factors contributing to the development of urinary tract infections, and they highlight new treatment strategies currently under development.

Morgan R. Timm
Seongmi K. Russell
Scott J. Hultgren
Reviews09 Sept 2024
Nature Reviews Microbiology

Volume: 23, P: 72-86
Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies

In this Review, Klein and Hultgren discuss recent advances in our understanding of the interplay between pathogens and the host during urinary tract infections, and how the insights into host–pathogen interactions and pathogenesis are guiding the development of antibiotic-sparing therapeutics.

Roger D. Klein
Scott J. Hultgren
Reviews18 Feb 2020
Nature Reviews Microbiology

Volume: 18, P: 211-226
Innate defense evicts bacterial squatters

Biofilms offer cover for many pathogenic bacteria. A recent paper in Nature reveals that lactoferrin is an innate tool that inhibits biofilm formation.

Creg Darby
Scott J. Hultgren
News & Views01 Jul 2002
Nature Immunology

Volume: 3, P: 602-604
Crystal structure of the FimD usher bound to its cognate FimC–FimH substrate

Gilles Phan
Han Remaut
Gabriel Waksman
Research01 Jun 2011
Nature

Volume: 474, P: 49-53
Gas Chromatography

C. G. SCOTT
News01 Dec 1962
Nature

Volume: 196, P: 817-819
Molecular Characterization of the Interaction Between HifB and HifA in the Biogenesis of H. influenzae Hemagglutinating Pili 867

Graham P Krasan
Scott J Hultgren
Joseph W St Geme III
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 150
Bacteria thread the needle

When bacteria attack another organism, one of the first steps is the injection of 'virulence effector proteins' into its cells. Two of the main players in such a system have been caught in action.

Craig L. Smith
Scott J. Hultgren
News & Views01 Nov 2001
Nature

Volume: 414, P: 29-31
Anthrax hijacks host receptor

An atomic picture of how anthrax toxin binds to its host's cells reveals that the toxin commandeers a host receptor protein and tricks it into helping the toxin enter the cell.

James G. Bann
Scott J. Hultgren
News & Views18 Aug 2004
Nature

Volume: 430, P: 843-844
The pilus usher controls protein interactions via domain masking and is functional as an oligomer

Biochemical analyses show that in the Escherichia coli type I pilus the plug domain controls activation of usher by masking the substrate-binding site in the C-terminal domains when usher is in resting state.

Glenn T Werneburg
Nadine S Henderson
David G Thanassi
Research08 Jun 2015
Nature Structural & Molecular Biology

Volume: 22, P: 540-546
Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection

Wei Xu
Ana L. Flores-Mireles
Michael G. Caparon
ResearchOpen Access06 Nov 2017
npj Biofilms and Microbiomes

Volume: 3, P: 1-12
Insights into the Microbiome of Breast Implants and Periprosthetic Tissue in Breast Implant-Associated Anaplastic Large Cell Lymphoma

Jennifer N. Walker
Blake M. Hanson
Terence M. Myckatyn
ResearchOpen Access17 Jul 2019
Scientific Reports

Volume: 9, P: 1-12
Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG

CsgG and CgsE form an encaging translocon for selective, iterative diffusion of curli subunits across the non-energized bacterial outer membrane.

Parveen Goyal
Petya V. Krasteva
Han Remaut
Research14 Sept 2014
Nature

Volume: 516, P: 250-253
Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

In this Review, Schwechheimer and Kuehn describe recent developments in elucidating the mechanisms of biogenesis and cargo selection of the outer-membrane vesicles (OMVs) produced by Gram-negative bacteria. They also discuss the functions of OMVs in bacterial physiology and during pathogenesis.

Carmen Schwechheimer
Meta J. Kuehn
Reviews16 Sept 2015
Nature Reviews Microbiology

Volume: 13, P: 605-619
Precision antimicrobial therapeutics: the path of least resistance?

Caitlin N. Spaulding
Roger D. Klein
Scott J. Hultgren
ReviewsOpen Access27 Feb 2018
npj Biofilms and Microbiomes

Volume: 4, P: 1-7

Search

P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

Vaccination with Acinetobacter baumannii adhesin Abp2D provides protection against catheter-associated urinary tract infection

Urinary tract infections: epidemiology, mechanisms of infection and treatment options

Author Correction: Longitudinal profiling of low-abundance strains in microbiomes with ChronoStrain

Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome

Structural biology of the chaperone–usher pathway of pilus biogenesis

Longitudinal profiling of low-abundance strains in microbiomes with ChronoStrain

Microbial co-occurrences on catheters from long-term catheterized patients

Erratum: The biology and future prospects of antivirulence therapies

Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women

A murine model of urinary tract infection

Therapy for stressed bacteria

Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes

Morphological plasticity as a bacterial survival strategy

Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI

Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection

The biology and future prospects of antivirulence therapies

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease

Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli

Structural and energetic basis of folded-protein transport by the FimD usher

Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics

Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies

Innate defense evicts bacterial squatters

Crystal structure of the FimD usher bound to its cognate FimC–FimH substrate

Gas Chromatography

Molecular Characterization of the Interaction Between HifB and HifA in the Biogenesis of H. influenzae Hemagglutinating Pili 867

Bacteria thread the needle

Anthrax hijacks host receptor

The pilus usher controls protein interactions via domain masking and is functional as an oligomer

Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection

Insights into the Microbiome of Breast Implants and Periprosthetic Tissue in Breast Implant-Associated Anaplastic Large Cell Lymphoma

Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

Precision antimicrobial therapeutics: the path of least resistance?

Search

Quick links

Search

Filter By:

Search

Quick links