Nature Search

Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis

Anti-NMDA receptor encephalitis is a severe brain disorder caused by autoantibodies that trigger NMDA receptor loss. Here, the authors show that ART5803, a monovalent antibody, blocks this process and restores function in cell and primate models.

Atsuo Kanno
Takuya Kito
Mitsuyuki Matsumoto
ResearchOpen Access17 Jun 2025
Nature Communications

Volume: 16, P: 1-22
Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion

Maria I. Avrutsky
Crystal Colón Ortiz
Carol M. Troy
Amendments and CorrectionsOpen Access09 Jul 2020
Nature Communications

Volume: 11, P: 1
The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis

Patrick Mehlen
Shahrooz Rabizadeh
Dale E. Bredesen
Research22 Oct 1998
Nature

Volume: 395, P: 801-804
Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion

Retinal vein occlusion can cause blindness, and features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here the authors report a non-apoptotic role of endothelial caspase-9 in regulating blood-retina barrier integrity and neuronal survival, which can be therapeutically targeted in a mouse model of retinal vein occlusion.

Maria I. Avrutsky
Crystal Colón Ortiz
Carol M. Troy
ResearchOpen Access23 Jun 2020
Nature Communications

Volume: 11, P: 1-16
Structural and kinetic determinants of protease substrates

Identifying physiological substrates of proteases still poses a challenge. An unbiased approach using the heterologous Escherichia coli proteome now identifies the structural and sequence determinants for caspase-3 substrates, revealing a kinetic threshold that can distinguish relevant substrates.

John C Timmer
Wenhong Zhu
Guy S Salvesen
Research20 Sept 2009
Nature Structural & Molecular Biology

Volume: 16, P: 1101-1108
Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide

The lipopolysaccharide of the intracellular pathogen Shigella, in particular its O antigen, interacts with caspases and blocks their activation to prevent apoptosis.

Saskia D. Günther
Melanie Fritsch
Hamid Kashkar
Research23 Dec 2019
Nature Microbiology

Volume: 5, P: 354-367
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Gasdermin D is identified as the required substrate for pyroptosis, mediating caspase-11 function in the non-canonical inflammasome pathway; the cleaved N-terminal domain is shown to trigger pyroptosis.

Nobuhiko Kayagaki
Irma B. Stowe
Vishva M. Dixit
Research16 Sept 2015
Nature

Volume: 526, P: 666-671
The Fas–FADD death domain complex structure unravels signalling by receptor clustering

This study presents the crystal structure of a Fas-FADD complex, a central feature of the so-called death inducing signalling complex. The structure reveals a new mode of death domain interactions that allows four FADD and four Fas proteins in one complex.

Fiona L. Scott
Boguslaw Stec
Stefan J. Riedl
Research31 Dec 2008
Nature

Volume: 457, P: 1019-1022
Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes

Paulina Kasperkiewicz
Sonia Kołt
Marcin Drąg
ResearchOpen Access30 Oct 2018
Scientific Reports

Volume: 8, P: 1-10
Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells

Marcin Poreba
Wioletta Rut
Marcin Drag
Research11 Apr 2019
Cell Death & Differentiation

Volume: 26, P: 2695-2709
Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells

Katarzyna Groborz
Monica L. Gonzalez Ramirez
Marcin Poręba
Research17 Jun 2019
Cell Death & Differentiation

Volume: 27, P: 451-465
Caspase selective reagents for diagnosing apoptotic mechanisms

Marcin Poreba
Katarzyna Groborz
Guy S. Salvesen
Research10 May 2018
Cell Death & Differentiation

Volume: 26, P: 229-244
Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families

Marcin Poreba
Aleksandra Szalek
Marcin Drag
ResearchOpen Access23 Feb 2017
Scientific Reports

Volume: 7, P: 1-13

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