Nature Search

Developmental convergence and divergence in human stem cell models of autism

Risk associated with genetically defined forms of autism spectrum disorder (ASD) can propagate by means of transcriptional regulation to affect convergently dysregulated pathways, providing insight into the convergent impact of ASD genetic risk on human neurodevelopment.

Aaron Gordon
Se-Jin Yoon
Daniel H. Geschwind
ResearchOpen Access29 Jan 2026
Nature

P: 1-13
Protein methylation in cellular proliferation and differentiation: non-histone nuclear methyl acceptor protein(s) during 3'-methyl-4-dimethylaminoazobenzene-induced hepatocarcinogenesis

Moon-Kee Paik
Yoo-Jeong Han
Se-Jin Yoon
ResearchOpen Access01 Mar 1997
Experimental & Molecular Medicine

Volume: 29, P: 35-43
Arrays of Lucius microprisms for directional allocation of light and autostereoscopic three-dimensional displays

Autostereoscopic three-dimensional displays allow the perception of depth, by presenting offset images to the left and right eye, without the need for specialized glasses. Yoonet al propose a Luciusmicroprism array to control the directionality and intensity of light in three-dimensional displays.

Hyunsik Yoon
Sang-Guen Oh
Hong H. Lee
Research30 Aug 2011
Nature Communications

Volume: 2, P: 1-5
Correction: Corrigendum: The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice

Mi-Ran Lee
Chae-ji Lim
Goo Taeg Oh
Amendments and Corrections21 Jan 2015
Nature Communications

Volume: 6, P: 1-2
HEB associates with PRC2 and SMAD2/3 to regulate developmental fates

In embryonic stem cells, extracellular signals are required to derepress developmental promoters to drive lineage specification, but the proteins involved in this process remain unknown. Here the authors show that the protein HEB directly associates with the Polycomb repressive complex 2 at genes involved in mesoderm and endoderm specification.

Se-Jin Yoon
Joseph W. Foley
Julie C. Baker
Research16 Mar 2015
Nature Communications

Volume: 6, P: 1-12
The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice

Retnla is an adipokine with known roles in tissue repair and inflammation. Here Lee et al. show that Retnla also promotes cholesterol metabolism and excretion, thereby lowering blood cholesterol levels and reducing the development of atherosclerosis in mice.

Mi-Ran Lee
Chae-ji Lim
Goo Taeg Oh
Research15 Jul 2014
Nature Communications

Volume: 5, P: 1-15
Primate cell fusion disentangles gene regulatory divergence in neurodevelopment

Cortical organoids derived from tetraploid human–chimpanzee fused induced pluripotent stem cells provide a platform for untangling unique molecular features of human brain development.

Rachel M. Agoglia
Danqiong Sun
Hunter B. Fraser
Research17 Mar 2021
Nature

Volume: 592, P: 421-427
Long-term maturation of human cortical organoids matches key early postnatal transitions

Gordon et al. use genome-wide unbiased approaches to show that human cerebral cortical organoids, when cultured for many months, start to resemble stages of postnatal brain development, with a timeline that parallels in vivo development.

Aaron Gordon
Se-Jin Yoon
Daniel H. Geschwind
Research22 Feb 2021
Nature Neuroscience

Volume: 24, P: 331-342
Neuronal defects in a human cellular model of 22q11.2 deletion syndrome

A human stem cell–derived model helps to uncover neuronal phenotypes associated with genetic forms of neuropsychiatric disease.

Themasap A. Khan
Omer Revah
Sergiu P. Paşca
Research28 Sept 2020
Nature Medicine

Volume: 26, P: 1888-1898
Reliability of human cortical organoid generation

A protocol adapted to xeno- and feeder-free conditions is shown to generate reliable and consistent cortical brain organoids across differentiations and source stem cell lines, making it suitable for disease modeling and other applications.

Se-Jin Yoon
Lubayna S. Elahi
Sergiu P. Pașca
Research20 Dec 2018
Nature Methods

Volume: 16, P: 75-78
Single-cell transcriptomic landscape of the developing human spinal cord

Andersen, Thom and colleagues reveal the single-cell-resolution transcriptome of the midgestation human spinal cord and discover remarkable heterogeneity across and within cell types.

Jimena Andersen
Nicholas Thom
Sergiu P. Pașca
Research24 Apr 2023
Nature Neuroscience

Volume: 26, P: 902-914
Involvement of aquaporins in colorectal carcinogenesis

Chulso Moon
Jean-Charles Soria
Li Mao
Research02 Oct 2003
Oncogene

Volume: 22, P: 6699-6703
LGALS3 as a prognostic factor for classical Hodgkin’s lymphoma

Young Wha Koh
Se Jin Jung
Jooryung Huh
Research07 Mar 2014
Modern Pathology

Volume: 27, P: 1338-1344
Engineering brain assembloids to interrogate human neural circuits

A protocol is described for generating human brain assembloids and performing viral labeling and retrograde tracing, 3D live imaging of axon projection and optogenetics with calcium imaging and electrophysiological recordings to model neural circuits.

Yuki Miura
Min-Yin Li
Sergiu P. Pașca
Protocols06 Jan 2022
Nature Protocols

Volume: 17, P: 15-35

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Developmental convergence and divergence in human stem cell models of autism

Protein methylation in cellular proliferation and differentiation: non-histone nuclear methyl acceptor protein(s) during 3'-methyl-4-dimethylaminoazobenzene-induced hepatocarcinogenesis

Arrays of Lucius microprisms for directional allocation of light and autostereoscopic three-dimensional displays

Correction: Corrigendum: The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice

HEB associates with PRC2 and SMAD2/3 to regulate developmental fates

The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice

Primate cell fusion disentangles gene regulatory divergence in neurodevelopment

Long-term maturation of human cortical organoids matches key early postnatal transitions

Neuronal defects in a human cellular model of 22q11.2 deletion syndrome

Reliability of human cortical organoid generation

Single-cell transcriptomic landscape of the developing human spinal cord

Involvement of aquaporins in colorectal carcinogenesis

LGALS3 as a prognostic factor for classical Hodgkin’s lymphoma

Engineering brain assembloids to interrogate human neural circuits

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