Nature Search

Discovery and engineering of the antibody response to a prominent skin commensal

Staphylococcus epidermidis induces a potent, durable and specific antibody response that is conserved in humans and non-human primates, and which could be redirected against pathogens as a new form of topical vaccination.

Djenet Bousbaine
Katherine D. Bauman
Michael A. Fischbach
Research11 Dec 2024
Nature

Volume: 638, P: 1054-1064
Early childhood antibiotic utilization for infants discharged from the neonatal intensive care unit

Dustin D. Flannery
Molly Passarella
Karen M. Puopolo
Research05 Apr 2022
Journal of Perinatology

Volume: 42, P: 953-958
The Ability of Environmental Context to Facilitate Psychomotor Sensitization to Amphetamine Can Be Dissociated from Its Effect on Acute Drug Responsiveness and on Conditioned Responding

Hans S Crombag
Aldo Badiani
Terry E Robinson
Research01 Jun 2001
Neuropsychopharmacology

Volume: 24, P: 680-690
Reproducibility of real-world evidence studies using clinical practice data to inform regulatory and coverage decisions

Analyses of real-world evidence from digital clinical practice data provide important insights for healthcare decision makers. Here, authors test reproducibility of 150 peer-reviewed studies, reporting strong reproducibility, which could be further improved through more complete reporting in future original studies

Shirley V. Wang
Sushama Kattinakere Sreedhara
Deborah Zarin
ResearchOpen Access31 Aug 2022
Nature Communications

Volume: 13, P: 1-11
Burning embers: towards more transparent and robust climate-change risk assessments

Burning embers figures are used to represent climate-change risk and their transitions. This Review outlines the history and evolution of the burning embers concept, focusing on methodological shifts that increase transparency and allow for a more systematic elicitation process in Intergovernmental Panel on Climate Change (IPCC) reports.

Zinta Zommers
Philippe Marbaix
Margot Hulbert
Reviews10 Sept 2020
Nature Reviews Earth & Environment

Volume: 1, P: 516-529
Population-based screening to detect benzodiazepine drug-drug-drug interaction signals associated with unintentional traumatic injury

Cheng Chen
Sean Hennessy
Charles E. Leonard
ResearchOpen Access16 Sept 2022
Scientific Reports

Volume: 12, P: 1-10
Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer

Sean P. Kennedy
Michael O’Neill
Bryan T. Hennessy
ResearchOpen Access10 Feb 2020
Oncogene

Volume: 39, P: 3028-3040
Effect of statins on the association between high temperature and all-cause mortality in a socioeconomically disadvantaged population: a cohort study

Young Hee Nam
Warren B. Bilker
Sean Hennessy
ResearchOpen Access18 Mar 2019
Scientific Reports

Volume: 9, P: 1-10
Design and optimisation of dendrimer-conjugated Bcl-2/x_L inhibitor, AZD0466, with improved therapeutic index for cancer therapy

Claire Patterson et al. present the design and development of AZD0466, a drug-dendrimer conjugate, and use preclinical and mathematical models to determine the optimal release rate of the drug from the dendrimer carrier for maximal therapeutic index in terms of anti-tumour efficacy and cardiovascular tolerability. This study identifies this promising dual Bcl-2/Bcl-x_L inhibitor for progression to clinical development.

Claire M. Patterson
Srividya B. Balachander
Marianne B. Ashford
ResearchOpen Access25 Jan 2021
Communications Biology

Volume: 4, P: 1-14
Risk of sudden cardiac arrest and ventricular arrhythmia with sulfonylureas: An experience with conceptual replication in two independent populations

Neil Dhopeshwarkar
Colleen M. Brensinger
Charles E. Leonard
ResearchOpen Access22 Jun 2020
Scientific Reports

Volume: 10, P: 1-10
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Thromboembolic and neurologic sequelae of discontinuation of an antihyperlipidemic drug during ongoing warfarin therapy

Charles E. Leonard
Colleen M. Brensinger
Sean Hennessy
ResearchOpen Access21 Dec 2017
Scientific Reports

Volume: 7, P: 1-10
Publisher Correction: Effect of statins on the association between high temperature and all-cause mortality in a socioeconomically disadvantaged population: a cohort study

Young Hee Nam
Warren B. Bilker
Sean Hennessy
Amendments and CorrectionsOpen Access24 Jul 2019
Scientific Reports

Volume: 9, P: 1-2
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

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