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Showing 1–8 of 8 results
Advanced filters: Author: Sean M. Hartig Clear advanced filters

  • Aspartoacylase expression in white adipose tissue regulates circulating levels of N-acetylaspartate, which in turn modulates plasma pyrimidine levels and regulates postprandial body temperature.

    • Jessica B. Felix
    • Pradip K. Saha
    • Sean M. Hartig
    ResearchOpen Access
    Nature Metabolism
    Volume: 7, P: 1524-1535

  • AGO-CLIP permits the identification of miRNA target genes. Here, Hamilton et al. compile publicly available AGO-CLIP data and combine this information with miRNA analysis from The Cancer Genome Atlas, permitting the identification of an oncogenic miRNA superfamily that targets tumour suppressor genes.

    • Mark P. Hamilton
    • Kimal Rajapakshe
    • Sean E. McGuire
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-13

  • The metabolic dependencies of androgen receptor (AR)-driven growth in prostate adenocarcinoma are largely unknown but could represent a therapeutic target when hormonal manipulations fail. Here the authors demonstrate that the mitochondrial pyruvate carrier (MPC) is transcriptionally regulated by AR and that MPC inhibition suppresses tumour growth in hormone-responsive and castrate-resistant conditions.

    • David A. Bader
    • Sean M. Hartig
    • Sean E. McGuire
    Research
    Nature Metabolism
    Volume: 1, P: 70-85

  • An analysis of tree survival data from forest sites worldwide shows that in the tropics, rare tree species experience stronger stabilizing density dependence than common species, wheras no correlation of stabilizing density dependence and abundance exists in the temperate zone.

    • Lisa Hülsmann
    • Ryan A. Chisholm
    • Florian Hartig
    ResearchOpen Access
    Nature
    Volume: 627, P: 564-571

  • Type 2 diabetes is associated with chronic inflammation and is characterized by insulin resistance. Here, the authors identify a crucial role for endothelial BMPER function in glucose homeostasis, and BMPER overexpression was shown to alleviate insulin resistance and hyperglycemia in diabetic mice.

    • Hua Mao
    • Luge Li
    • Xinchun Pi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

    • Alexander S. Banks
    • David B. Allison
    • Juleen R. Zierath
    Reviews
    Nature Metabolism
    Volume: 7, P: 1765-1780

  • Early life exposure to environmental stressors, including endocrine disrupting chemicals (EDCs), can impact health later in life. Here, the authors show that neonatal EDC exposure in rats causes epigenetic reprogramming in the liver, which is transcriptionally silent until animals are placed on a Western-style diet.

    • Lindsey S. Treviño
    • Jianrong Dong
    • Cheryl Lyn Walker
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14