Nature Search

New Oral Chelating Agent for Treatment of Wilson's Disease

SEAN O'REILLY
WILLIAM BANK
Research01 Dec 1966
Nature

Volume: 212, P: 1597-1598
Facile generation of drug-like conformational antibodies specific for amyloid fibrils

A quantitative fluorescence-activated cell sorting method for generating fully human conformational antibodies against amyloid aggregates associated with neurodegenerative disorders—without the need for immunization—has now been developed. Engineered antibodies obtained using this approach show properties rivaling those of clinical-stage antibodies specific for tau and α-synuclein amyloid aggregates.

Alec A. Desai
Jennifer M. Zupancic
Peter M. Tessier
Research29 Apr 2025
Nature Chemical Biology

Volume: 21, P: 916-925
Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin

Weiguo Hu
Sean P Ferris
Xuebin Qin
Research23 Dec 2007
Nature Medicine

Volume: 14, P: 98-103
Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo

Activation of the non-canonical NF-κB signalling pathway by AZD5582 results in the induction of HIV and SIV RNA expression in the blood and tissues of antiretroviral-therapy-treated humanized mice and rhesus macaques.

Christopher C. Nixon
Maud Mavigner
J. Victor Garcia
Research22 Jan 2020
Nature

Volume: 578, P: 160-165
Lung adenocarcinoma promotion by air pollutants

Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

William Hill
Emilia L. Lim
Charles Swanton
Research05 Apr 2023
Nature

Volume: 616, P: 159-167
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

Analysis of whole-genome doubling (WGD) by using cancer sequencing data combined with simulations of tumor evolution suggests that there is negative selection against homozygous loss of essential genes before WGD but not after.

Saioa López
Emilia L. Lim
Nicholas McGranahan
Research05 Mar 2020
Nature Genetics

Volume: 52, P: 283-293
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

A survey of T cell repertoire evolution in the tumors, healthy tissue and blood of patients with early-stage untreated lung cancer offers an opportunity to monitor and identify neoantigen-specific T cells for personalized immunotherapy.

Kroopa Joshi
Marc Robert de Massy
Benny Chain
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1549-1559
A clonal expression biomarker associates with lung cancer mortality

TRACERx Lung: Intratumoral transcriptional heterogeneity, which often hinders the development of clinically useful RNA-expression-biased biomarkers for cancer, can now be overcome with an approach for the identification of clonal expression biomarkers.

Dhruva Biswas
Nicolai J. Birkbak
Angeles Montero
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1540-1548
Publisher Correction: Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Francesca Chemi
Dominic G. Rothwell
Jason Lester
Amendments and Corrections03 Jun 2020
Nature Medicine

Volume: 26, P: 1147
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Pulmonary venous tumor cells disseminating before tumor resection are heterogeneous, predict relapse and seed future metastasis of lung cancer

Francesca Chemi
Dominic G. Rothwell
Jason Lester
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1534-1539
The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Ghorani et al. use a multiomics approach to characterize the effect of tumour mutational burden on the differentiation of CD4 and CD8 T cell subpopulations in non-small cell lung cancer.

Ehsan Ghorani
James L. Reading
Sergio A. Quezada
Research22 May 2020
Nature Cancer

Volume: 1, P: 546-561
Geospatial immune variability illuminates differential evolution of lung adenocarcinoma

Multiregion spatial histology, exome and transcriptome data from patients with non-small cell lung cancer suggest that cancer subclones from immune cold regions diversify later than subclones from immune hot regions

Khalid AbdulJabbar
Shan E. Ahmed Raza
Yinyin Yuan
Research27 May 2020
Nature Medicine

Volume: 26, P: 1054-1062
Clinically relevant acute subjective effects of psychedelics beyond mystical experience

The therapeutic benefits of psychedelics might be ascribed to their subjective effects, but methodological barriers limit interpretation of this association. In this Review, Yaden et al. balance the limitations of current assessments with research advances to inform the development of new measures and practices for understanding the clinical implications of psychedelics.

David B. Yaden
Sean P. Goldy
Roland R. Griffiths
Reviews03 Sept 2024
Nature Reviews Psychology

Volume: 3, P: 606-621
Industrial-age doubling of snow accumulation in the Alaska Range linked to tropical ocean warming

Dominic Winski
Erich Osterberg
Michael Handley
ResearchOpen Access19 Dec 2017
Scientific Reports

Volume: 7, P: 1-12

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