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Showing 1–5 of 5 results
Advanced filters: Author: Sebald A. N. Verkuijl Clear advanced filters

  • CRISPR/Cas9-based homing gene drives have emerged as a potential new approach to mosquito control. Here the authors use transgenic lines with germline-specific regulatory elements to express Cas9 and achieve up to 94% inheritance bias, closing the gap between A. aegyptidrives and the highly efficient drives observed in Anopheles species.

    • Michelle A. E. Anderson
    • Estela Gonzalez
    • Luke Alphey
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9

  • Here, the authors describe a highly efficient gene drive targeting the non-coding miR-184 gene. Disruption of the miR-184 gene by the gene drive reduces mosquito lifespan and interferes with survival after a blood meal, both traits that may reduce malaria burden.

    • Sebald A. N. Verkuijl
    • Giuseppe Del Corsano
    • Nikolai Windbichler
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • CRISPR/Cas gene drives can bias transgene inheritance through different mechanisms. Here the authors use gene linkage to show that in males inheritance bias of wGDe did not occur by homing, rather through increased propagation of the donor drive element.

    • Sebald A. N. Verkuijl
    • Estela Gonzalez
    • Luke Alphey
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Aedes aegypti is the main vector of several major pathogens including dengue, Zika and chikungunya viruses. Here the authors find that a CRISPR/Cas9 based split gene drive in Aedes aegypti could successfully bias inheritance up to 89% over successive generations in a multi-cage trial with further deep sequencing suggesting that the multiplexing design could mitigate resistance allele formation.

    • Michelle A. E. Anderson
    • Estela Gonzalez
    • Luke Alphey
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Priscilla Y. L. Tng et al. report a Cas13b-dependent way to suppress the transmissibility of RNA viruses chikungunya and dengue in mosquitoes. They use a virus-derived reporter and a CHIKV split replication system and demonstrate that Cas13b and gRNAs can inhibit virus-derived reporter RNAs in insect cells in vitro.

    • Priscilla Ying Lei Tng
    • Leonela Carabajal Paladino
    • Luke Alphey
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-9