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Showing 1–2 of 2 results
Advanced filters: Author: Sebastiaan Vanuytven Clear advanced filters

  • Netrin-1 is upregulated in cancer models that undergo spontaneous epithelial-to-mesenchymal transition, and its targeting blocks the progression of tumour cells to a late mesenchymal state, suggesting possible therapeutic applications.

    • Justine Lengrand
    • Ievgenia Pastushenko
    • Cédric Blanpain
    Research
    Nature
    Volume: 620, P: 402-408

  • The mechanisms that shape the regulatory T cell repertoire in patients with cancer are not completely understood. Here, the authors observe that, in breast cancer patients, tumor-resident regulatory T cells do not show clonal relationship with their circulating counterpart, but share a common origin with intratumoral antigen-experienced conventional T cells.

    • Maria Xydia
    • Raheleh Rahbari
    • Philipp Beckhove
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18