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Showing 1–4 of 4 results
Advanced filters: Author: Sebastian Arangundy-Franklin Clear advanced filters

  • The most recent class of base editors utilize DddAtox, a deaminase domain that can act upon double-stranded DNA. Here the authors target DddAtox fragments and a FokI-based nickase to the human CIITA gene by fusing these domains to arrays of engineered zinc fingers; they also identify a variety of DddAtox orthologues.

    • Friedrich Fauser
    • Bhakti N. Kadam
    • Jeffrey C. Miller
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Sterically demanding 2′-modified nucleotides used in antisense therapeutics have thus far been challenging to synthesise enzymatically. Now, it has been shown that mutation of two gatekeeper residues in an archaeal DNA polymerase unlocks efficient synthesis of the modified nucleic acid oligomers 2′-O-methyl-RNA and 2′-O-(2-methoxyethyl)-RNA and enables the evolution of 2′-O-methyl-RNA enzymes.

    • Niklas Freund
    • Alexander I. Taylor
    • Philipp Holliger
    Research
    Nature Chemistry
    Volume: 15, P: 91-100

  • Engineering reverse transcriptases for modified or unnatural nucleic acids is challenging, but now a versatile method has been developed that enables the discovery of efficient reverse transcriptases. The method works with a wide range of template structures, including xeno-nucleic acids and can also be used to produce high-fidelity reverse transcriptases for RNA.

    • Gillian Houlihan
    • Sebastian Arangundy-Franklin
    • Philipp Holliger
    Research
    Nature Chemistry
    Volume: 12, P: 683-690

  • The highly charged phosphodiester chemistry of the natural nucleic acids DNA and RNA has been widely considered to be indispensable for their function as informational molecules. Now, synthetic genetic polymers with an uncharged alkyl phosphonate backbone chemistry have been shown to enable genetic information transfer and evolution.

    • Sebastian Arangundy-Franklin
    • Alexander I. Taylor
    • Philipp Holliger
    Research
    Nature Chemistry
    Volume: 11, P: 533-542