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A metabolism-chromatin axis promotes differential ribosomal RNA transcription in the human malaria parasite

How is specific ribosomal RNA expression precisely controlled in the malaria parasite? Dr. Couble et al. show that a switch between distinct energy-generating pathways during parasite development directly impacts the accessibility to rDNA chromatin.

Justine E. Couble
Tiziano Vignolini
Sebastian Baumgarten
ResearchOpen Access19 Dec 2025
Nature Communications

Volume: 17, P: 1-18
High-resolution map of the Plasmodium falciparum genome reveals MORC/ApiAP2-mediated links between distant, functionally related genes

Micro-C provides insights into genome organization in Plasmodium falciparum and defines the machinery used to spatially coordinate antigenic variation and stage-specific genes that are crucial for infection.

Parul Singh
Jacques Serizay
Jessica M. Bryant
ResearchOpen Access30 Jun 2025
Nature Microbiology

Volume: 10, P: 1665-1683
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

A single-cell screening approach identifies targets for CAR-T cells in acute myeloid leukemia.

Adrian Gottschlich
Moritz Thomas
Sebastian Kobold
Research13 Mar 2023
Nature Biotechnology

Volume: 41, P: 1618-1632
Transcriptome-wide dynamics of extensive m⁶A mRNA methylation during Plasmodium falciparum blood-stage development

An analysis of mRNA modifications in Plasmodium falciparum reveals m⁶A dynamics associated with parasite development within human red blood cells. m⁶A methylation is regulated by the methyltransferase PfMT-A70 and is linked to mRNA stability or translational efficiency.

Sebastian Baumgarten
Jessica M. Bryant
Artur Scherf
Research05 Aug 2019
Nature Microbiology

Volume: 4, P: 2246-2259
Infographic: SPECTRUM: study design of the global real-world study of aflibercept 8 mg in the treatment of neovascular age-related macular degeneration and diabetic macular edema

Clare Bailey
Clemens Lange
Vasileios Konidaris
ResearchOpen Access16 Jan 2026
Eye

P: 1-4
Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis

Plasmacytoid dendritic cells monitor the bone marrow for apoptotic megakaryocytes (MKs) and deliver IFNα to the MK niche, triggering local on-demand proliferation and maturation of MK progenitors.

Florian Gaertner
Hellen Ishikawa-Ankerhold
Steffen Massberg
ResearchOpen Access10 Jul 2024
Nature

Volume: 631, P: 645-653
Comparative analysis of the genomes of Stylophora pistillata and Acropora digitifera provides evidence for extensive differences between species of corals

Christian R. Voolstra
Yong Li
Manuel Aranda
ResearchOpen Access14 Dec 2017
Scientific Reports

Volume: 7, P: 1-14
Aiptasia sp. larvae as a model to reveal mechanisms of symbiont selection in cnidarians

Iliona Wolfowicz
Sebastian Baumgarten
Annika Guse
ResearchOpen Access01 Sept 2016
Scientific Reports

Volume: 6, P: 1-12
Extent and prognostic value of MGMT promotor methylation in glioma WHO grade II

Philipp Karschnia
Nico Teske
Niklas Thon
ResearchOpen Access12 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
Linezolid, vancomycin and daptomycin modulate cytokine production, Toll-like receptors and phagocytosis in a human in vitro model of sepsis

Christian Bode
Stefan Muenster
Georg Baumgarten
ResearchOpen Access04 Mar 2015
The Journal of Antibiotics

Volume: 68, P: 485-490
Rapid activation of distinct members of multigene families in Plasmodium spp

Omelianczyk, Loh et al. activate the expression of a single member of a multigene family in Plasmodium spp. from its endogenous promoter, identifying differences between the different families. This study supports the application of the Selection Linked Integration method for studying multigene families in Plasmodium.

Radoslaw Igor Omelianczyk
Han Ping Loh
Peter R. Preiser
ResearchOpen Access03 Jul 2020
Communications Biology

Volume: 3, P: 1-11
Impact of the selective A2_AR and A2_BR dual antagonist AB928/etrumadenant on CAR T cell function

Matthias Seifert
Mohamed-Reda Benmebarek
Sebastian Kobold
ResearchOpen Access20 Oct 2022
British Journal of Cancer

Volume: 127, P: 2175-2185
Transcriptomes and expression profiling of deep-sea corals from the Red Sea provide insight into the biology of azooxanthellate corals

Lauren K. Yum
Sebastian Baumgarten
Christian R. Voolstra
ResearchOpen Access25 Jul 2017
Scientific Reports

Volume: 7, P: 1-11

Search

A metabolism-chromatin axis promotes differential ribosomal RNA transcription in the human malaria parasite

High-resolution map of the Plasmodium falciparum genome reveals MORC/ApiAP2-mediated links between distant, functionally related genes

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

Transcriptome-wide dynamics of extensive m⁶A mRNA methylation during Plasmodium falciparum blood-stage development

Infographic: SPECTRUM: study design of the global real-world study of aflibercept 8 mg in the treatment of neovascular age-related macular degeneration and diabetic macular edema

Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis

Comparative analysis of the genomes of Stylophora pistillata and Acropora digitifera provides evidence for extensive differences between species of corals

Aiptasia sp. larvae as a model to reveal mechanisms of symbiont selection in cnidarians

Extent and prognostic value of MGMT promotor methylation in glioma WHO grade II

Linezolid, vancomycin and daptomycin modulate cytokine production, Toll-like receptors and phagocytosis in a human in vitro model of sepsis

Rapid activation of distinct members of multigene families in Plasmodium spp

Impact of the selective A2_AR and A2_BR dual antagonist AB928/etrumadenant on CAR T cell function

Transcriptomes and expression profiling of deep-sea corals from the Red Sea provide insight into the biology of azooxanthellate corals

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