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Showing 1–4 of 4 results

Advanced filters: Author: Sebastian Fenn Clear advanced filters

DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously

Bispecific antibodies can bind to two distinct targets though the fusion of two different Fv regions. In this study, the authors develop DutaFabs that present two separated and independent antigen binding sites within the same Fv region, giving rise to bispecific Fab fragments.

Roland Beckmann
Kristian Jensen
Hubert Kettenberger
ResearchOpen Access29 Jan 2021
Nature Communications

Volume: 12, P: 1-13
Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results

Interim results from the low-dose cohort of the PROCLAIM trial show that AAV-based delivery of the progranulin gene in patients with frontotemporal dementia was safe and was associated with increased CSF progranulin.

Jeffrey Sevigny
Olga Uspenskaya
Franz Hefti
ResearchOpen Access14 May 2024
Nature Medicine

Volume: 30, P: 1406-1415
Long single α-helical tail domains bridge the gap between structure and function of myosin VI

Benjamin J Spink
Sivaraj Sivaramakrishnan
James A Spudich
Research30 May 2008
Nature Structural & Molecular Biology

Volume: 15, P: 591-597
A modular and controllable T cell therapy platform for acute myeloid leukemia

Mohamed-Reda Benmebarek
Bruno L. Cadilha
Sebastian Kobold
ResearchOpen Access07 Jan 2021
Leukemia

Volume: 35, P: 2243-2257