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Showing 1–2 of 2 results
Advanced filters: Author: Sebastian G. Wicha Clear advanced filters
  • Here the authors use drug susceptibility data from Plasmodium falciparum field isolates in a pharmacometric model to evaluate cabamiquine and pyronaridine efficacy, both individually and in combination. The combined treatment shows over 90% parasite reduction in most simulated cases, providing valuable guidance for clinical dose selection in real-world settings.

    • Mohamed Maiga
    • Laurent Dembele
    • Claudia Demarta-Gatsi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11
  • Assessment of pharmacodynamic interactions is at the heart of combination therapy development. Here the authors introduce a general drug interaction scoring model that enables quantification of synergistic and antagonistic interactions and determination of the directionality of the interactions.

    • Sebastian G. Wicha
    • Chunli Chen
    • Ulrika S. H. Simonsson
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11