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Showing 1–12 of 12 results
Advanced filters: Author: Sebastian J. Streichan Clear advanced filters

  • Chen et al. show that in mice, extracellular matrix remodeling drives early migration of the anterior signaling center, establishing the body axis sooner than expected—a mechanism potentially conserved in humans.

    • Dong-Yuan Chen
    • Nikolas H. Claussen
    • Magdalena Zernicka-Goetz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • How does DNA encode shape? Here, via in toto light sheet microscopy and optogenetic control of cellular forces, the authors show that spatially patterned mechanical feedback loops establish the cytoskeletal patterns driving axis elongation tissue flow in Drosophila.

    • Hannah J. Gustafson
    • Nikolas Claussen
    • Sebastian J. Streichan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Early positioning of the embryo nuclei is not well understood. Now, experiments show that the orientation of the mitotic spindle is controlled by topological interactions, which determine whether the nucleus remains inside the Drosophila embryo.

    • Woonyung Hur
    • Arghyadip Mukherjee
    • Stefano Di Talia
    Research
    Nature Physics
    Volume: 21, P: 632-643

  • Handling and quantitative image analysis of layered tissues is greatly simplified by cartography with the Image Surface Analysis Environment (ImSAnE), as demonstrated on a variety of specimens, including a beating heart.

    • Idse Heemskerk
    • Sebastian J Streichan
    Research
    Nature Methods
    Volume: 12, P: 1139-1142

  • The extracellular matrix can shape developing organs, but how external forces direct intercellular morphogenesis is unclear. Here, the authors use 3D imaging to show that elongation of the Drosophila egg chamber involves polarized cell reorientation signalled by changes in stiffness of the surrounding extracellular matrix.

    • Dong-Yuan Chen
    • Justin Crest
    • David Bilder
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • During epithelial morphogenesis in Drosophila, the villous apical cell surface is flattened. Fabrowski et al. show that this flattening depends on a dramatic increase in endocytosis associated with the formation of tubular invaginations, revealing a role for membrane trafficking in morphological remodelling.

    • Piotr Fabrowski
    • Aleksandar S. Necakov
    • Stefano De Renzis
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-12

  • Neural crest cells arise within the central nervous system, then migrate and contribute to a variety of cell types. Here, the authors use multiplex transcript analysis at single cell  resolution to define neural crest and neural subpopulations within the avian neural tube, including a neural crest stem cell niche.

    • Antti Lignell
    • Laura Kerosuo
    • Marianne E. Bronner
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • A selective-plane illumination microscope with two illumination and two detection objectives rapidly records four three-dimensional images of an entire developing fly embryo and processes them into a single high-content image in real time. This allows for cell tracking and quantification of cell shape changes across the embryo. A related paper by Tomer et al. is also in this issue.

    • Uros Krzic
    • Stefan Gunther
    • Lars Hufnagel
    Research
    Nature Methods
    Volume: 9, P: 730-733